Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
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DOI：
10.1161/01.cir.95.8.2068
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发表时间：
1997-04-15
期刊：
影响因子：
37.8
通讯作者：
Frolich, JC
中科院分区：
文献类型：
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作者：
Boger, RH;BodeBoger, SM;Frolich, JC
研究了77例周围动脉闭塞性疾病（pad）ⅱb ~ⅳ期患者以及47例青年和37例老年健康对照者的尿硝酸盐和cGMP排泄率、全身NO形成指标、l -精氨酸和内源性NO合成酶抑制剂不对称二甲基精氨酸（ADMA）及其无活性立体异构体对称二甲基精氨酸（对称二甲基精氨酸）血浆浓度。方法与结果年轻健康对照者尿硝酸盐排泄量为182.0+/-11.4 μ mol/mmol肌酐，cGMP排泄量为186.2+/-13.0 nmol/mmol肌酐。在老年对照组中，两种排泄率均略低（硝酸盐，156.0+/-7.8 mu mol/mmol肌酐；cGMP, 150.0+/-8.3 nmol/mmol肌酐；P=NS）。在pad患者中，尿硝酸盐有显著的进行性降低(IIb, 138.4+/-11.9； III, 128.6+/-11.3； IV, 91.9+/-8.0 mu mol/mmol肌酐；P
Background We studied urinary nitrate and cGMP excretion rates, indices of systemic NO formation, and plasma concentrations of L-arginine and the endogenous NO synthase inhibitor asymmetrical dimethylarginine (ADMA) and its inactive stereoisomer, symmetrical dimethylarginine, in 77 patients with peripheral arterial occlusive disease (PAOD) in Fontaine stages IIb through IV and in 47 young and 37 elderly healthy control subjects.Methods and Results Urinary nitrate excretion was 182.0+/-11.4 mu mol/mmol creatinine and cGMP excretion was 186.2+/-13.0 nmol/mmol creatinine in young healthy control subjects. In elderly control subjects, both excretion rates were slightly lower (nitrate, 156.0+/-7.8 mu mol/mmol creatinine; cGMP, 150.0+/-8.3 nmol/mmol creatinine; P=NS). In PAOD patients, there was a significant, progressive reduction of urinary nitrate (IIb, 138.4+/-11.9; III, 128.6+/-11.3; and IV, 91.9+/-8.0 mu mol/mmol creatinine; P