Plasma and urinary catecholamines in salt-sensitive idiopathic hypertension.
Plasma and urinary catecholamines in salt-sensitive idiopathic hypertension.
复制标题
盐敏感性特发性高血压的血浆和尿儿茶酚胺。
作者：
Jr Jr Gill;G. Güllner;CR Lake;DJ Lakatua;G. Lan
19例肾素正常的特发性高血压患者，根据其平均动脉压在增加钠摄入量时是否升高8%或以上，随机分为盐敏感型或耐盐型。这两个亚组和5名正常受试者对每天摄入9、109和249mEq的钠的反应如下：盐敏感受试者每天摄入9、109和249mEq的钠比正常摄入量的受试者保留更多的钠，当他们摄入高钠时，血或尿去甲肾上腺素没有下降；尿多巴胺正常，但当钠摄入量增加时，尿多巴胺不正常增加。耐盐受试者钠排泄正常，高钠摄入时血、尿去甲肾上腺素分别下降30%和37%；尿多巴胺超常，随钠摄入量增加不再进一步增加。高血压患者在高钠摄入过程中的累积钠滞留与血浆去甲肾上腺素的变化百分率直接相关，提示肾脏肾上腺素能活动是盐敏感患者钠排泄受损的一个因素。在高血压患者中，累积的钠滞留和血浆去甲肾上腺素的变化百分比与尿多巴胺呈负相关，这表明耐盐患者肾脏和神经组织中多巴胺的形成增加可能是导致肾脏和肾上腺素对高钠摄入量的反应亚群不同的原因。
Nineteen patients with normal renin idiopathic hypertension were arbitrarily classified as salt-sensitive or salt-resistant depending on whether their mean arterial pressure did or did not increase by 8% or more when sodium intake was increased. The responses of the two subsets and of five normal subjects to sodium intakes of 9, 109, and 249 mEq/day given for 7 days were as follows: The salt-sensitive subjects retained more sodium than normal and plasma or urinary norepinephrine did not decrease when they were given a high sodium intake; urinary dopamine was normal but did not increase normally when sodium intake was increased. The salt-resistant subjects excreted sodium normally and plasma and urinary norepinephrine was decreased by 30 and 37%, respectively, when they were given a high sodium intake; urinary dopamine was supernormal and did not increase further when sodium intake was increased. Cumulative sodium retention during the high sodium intake was directly related to the percentage of change in plasma norepinephrine in the hypertensive subjects, suggesting that renal adrenergic activity was a factor in the impaired sodium excretion in the salt-sensitive patients. Cumulative sodium retention and the percentage of change in plasma norepinephrine were inversely related to urinary dopamine in the hypertensive subjects, suggesting that increased formation of dopamine in renal and neural tissue in the salt-resistant subjects may have been responsible for the differences between the subsets in renal and adrenergic responses to a high sodium intake.(ABSTRACT TRUNCATED AT 250 WORDS)
血浆儿茶酚胺调节正常血压和高血压人血小板中α2肾上腺素受体激动剂亲和力和敏感性。
DOI：
10.1172/jci112452
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Hollister,AS;Onrot,J;Lonce,S;Nadeau,JH;Robertson,D
通讯作者：
Robertson,D
原发性高血压患者对盐水输注的肾脏和内分泌反应。
DOI：
10.1161/01.hyp.8.3.217
发表时间：
1986
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Rydstedt,LL;Williams,GH;Hollenberg,NK
通讯作者：
Hollenberg,NK
DOI：
10.3109/10641968209061609
发表时间：
1982
期刊：
Clinical and experimental hypertension. Part A, Theory and practice
影响因子：
--
作者：
Weinberger,MH;Luft,FC;Henry,DP
通讯作者：
Henry,DP