Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response.
Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response.
复制标题
抑制受损作为 PTSD 风险和治疗反应的中间表型。
DOI：
10.1016/j.pnpbp.2018.10.014
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发表时间：
2019
影响因子：
5.6
通讯作者：
Jovanovic,Tanja
中科院分区：
文献类型：
--
作者：
vanRooij,SanneJH;Jovanovic,Tanja
对恐惧的抑制包括学习，然后对安全信号做出适当的反应，这在创伤后应激障碍患者中被证明是受损的。反应抑制指的是认知控制，可能与恐惧抑制使用相同的前额皮质回路，也与创伤后应激障碍有关。抑制受损可以作为创伤后应激障碍的中间表型，可以用神经影像学和心理生理学工具来测量。我们首先回顾恐惧和反应抑制的神经生物学机制。接下来，我们总结了功能磁共振成像（fMRI）和心理生理研究在PTSD患者恐惧和反应抑制范式中的应用。最后，我们评估了抑制受损在PTSD风险和治疗反应中的治疗作用。
Inhibition of fear involves learning and then appropriately responding to safety signals, and has been shown to be impaired in PTSD patients. Response inhibition refers to cognitive control and likely uses the same prefrontal cortex circuits as fear inhibition, and has also been implicated in PTSD. Impaired inhibition can serve as an intermediate phenotype for PTSD and can be measured with neuroimaging and psychophysiological tools. We first review the neurobiological mechanisms of fear and response inhibition. Next, we summarize the functional magnetic resonance imaging (fMRI) and psychophysiological studies using fear and response inhibition paradigms in PTSD patients. Finally, we evaluate the theranostic role of impaired inhibition in PTSD risk and treatment response.