Towards structural models of molecular recognition in olfactory receptors
Towards structural models of molecular recognition in olfactory receptors
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DOI：
10.1016/s0300-9084(98)80019-9
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发表时间：
1998-02-01
期刊：
影响因子：
3.9
通讯作者：
Demaille, J
中科院分区：
文献类型：
--
作者：
Afshar, M;Hubbard, RE;Demaille, J
G蛋白偶联受体（GPCR）是一类重要的蛋白质，作为信号转导通过细胞质膜。了解这些蛋白质的结构和激活机制对于理解细胞信号传导的许多不同方面至关重要。嗅觉受体对应于GPCR的最大家族。关于受体的结构如何控制相互作用的特异性，从而能够识别特定的气味分子，我们知之甚少。在本文中，我们回顾了最近的事态发展，在两个领域的分子建模：跨膜螺旋的配置建模方法和自动对接的配体到受体结构的方法。然后，我们展示了如何将这些方法的一个子集相结合，构建一个模型的大鼠气味受体相互作用与Lyral的实验数据是可用的。这种建模可以帮助我们在阐明受体和气味分子之间相互作用的特异性方面取得进展。((C)法国生物化学与分子生物学协会/爱思唯尔，巴黎）。
The G protein coupled receptors (GPCR) are an important class of proteins that act as signal transducers through the cytoplasmic membrane. Understanding the structure and activation mechanism of these proteins is crucial for understanding many different aspects of cellular signalling. The olfactory receptors correspond to the largest family of GPCRs. Very little is known about how the structures of the receptors govern the specificity of interaction which enables identification of particular odorant molecules. In this paper, we review recent developments in two areas of molecular modelling: methods for modelling the configuration of trans-membrane helices and methods for automatic docking of ligands into receptor structures. We then show how a subset of these methods can be combined to construct a model of a rat odorant receptor interacting with lyral for which experimental data are available. This modelling can help us make progress towards elucidating the specificity of interactions between receptors and odorant molecules. ((C) Societe francaise de biochimie et biologie moleculaire/Elsevier, Paris).