Methylphenidate improves stroop naming speed, but not response interference, in children with attention deficit hyperactivity disorder
Methylphenidate improves stroop naming speed, but not response interference, in children with attention deficit hyperactivity disorder
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DOI：
10.1089/104454602762599844
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发表时间：
2002-12-01
影响因子：
1.9
通讯作者：
Tannock, R
中科院分区：
文献类型：
--
作者：
Bedard, AC;Ickowicz, A;Tannock, R
目的：本研究的目的是探讨哌醋甲酯（MPH）对注意缺陷多动障碍（ADHD）儿童反应干扰的影响（通过Stoop Color and Word Test测量）。反应干扰是反应抑制的核心组成部分，在患有多动症的儿童中被证明是受损的。方法：临床参考样本为经精神障碍诊断与统计手册（第4版）确诊为ADHD且阅读能力良好的学龄儿童（n = 31），在一项急性、随机、安慰剂对照、使用三种单一固定剂量MPH的交叉试验中完成Stroop颜色和单词测试。结果：MPH没有改善Stroop颜色和单词测试的反应干扰，但显著提高了颜色命名和单词命名能力。结论：Stroop Color and Word Test测量的ADHD儿童的反应干扰，MPH并没有改善。此外，研究结果表明，MPH对高度费力的颜色命名过程有强烈的积极影响，这一过程在ADHD儿童中被证明是受损的。MPH也被证明对单词命名速度有积极但较小的影响。
Objective: The goal of this study was to investigate the effect of methylphenidate (MPH) on response interference, as measured by the Stoop Color and Word Test, in children with attention deficit hyperactivity disorder (ADHD). Response interference is a core component of response inhibition that has been shown to be impaired in children with ADHD.Methods: A clinic-referred sample of school-aged children with a confirmed Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnosis of ADHD and good reading skills (n = 31) completed the Stroop Color and Word Test in an acute, randomized, placebo-controlled, crossover trial with three single fixed doses of MPH.Results: MPH did not improve response interference on the Stroop Color and Word Test but did significantly improve color naming and word naming abilities.Conclusion: Response interference, as measured by the Stroop Color and Word Test, is not improved by MPH in children with ADHD. In addition, findings demonstrate strongly positive MPH effects on the highly effortful process of color naming, which has previously been demonstrated as impaired in children with ADHD. MPH was also shown to have a positive but smaller effect on word naming speed.