Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: an in vitro study
Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: an in vitro study
复制标题
磁性纳米气泡具有乳腺癌靶向药物输送和三模态成像的潜力：一项体外研究
DOI：
10.2217/nnm-2017-0027
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发表时间：
2017-05-01
期刊：
影响因子：
5.5
通讯作者：
Guo, Dajing
中科院分区：
文献类型：
--
作者：
Song, Weixiang;Luo, Yindeng;Guo, Dajing
本研究的目的是通过设计具有靶向药物递送和多模态成像潜力的磁性纳米泡来改善乳腺癌的肿瘤靶向治疗。材料和方法：采用改进的复乳蒸发法结合碳二亚胺技术制备了赫赛汀修饰的超小超顺磁性氧化铁（USPIO）/紫杉醇（PTX）包埋纳米泡（PTX-USPIO-HER-NBs）。检查了PTX-USPIOHER-NB的表征、特异性细胞靶向能力和多模式成像。结果如下：PTX-USPIO-HER-NB表现出赫赛汀/PTX/USPIO的优异包封率，并显示出比其他递送平台更大的细胞毒性作用。低频超声波加速了PTX的释放。此外，磁性纳米气泡能够增强超声、磁共振和光声三模态成像。结论：这些结果表明，PTX-USPIO-HER-NB具有作为多模式造影剂和作为乳腺癌中超声触发药物释放系统的潜力。
The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. Materials & methods: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIOHER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging. Results: PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging. Conclusion: These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.