A 100-channel hermetically sealed implantable device for chronic wireless neurosensing applications.
A 100-channel hermetically sealed implantable device for chronic wireless neurosensing applications.
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DOI：
10.1109/tbcas.2013.2255874
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发表时间：
2013-04
影响因子：
5.1
通讯作者：
Nurmikko AV
中科院分区：
文献类型：
--
作者：
Yin M;Borton DA;Aceros J;Patterson WR;Nurmikko AV
研制了一种100通道全植入式无线宽带神经记录系统。它具有100个并行宽带(0.1赫兹-7.8千赫兹)神经记录通道、一个医用级200毫安锂离子电池以150千赫兹感应充电，以及使用3.2 GHz至3.8 GHz FSK调制无线链路传输48 Mbps曼彻斯特编码数据的数据遥测。所有有源电子设备都密封在钛外壳中，带有蓝宝石窗口，以实现电磁透明。100个单独的密封式馈通引脚的定制高密度配置使其能够连接到皮质内神经记录微电极阵列。设计了一个100MHZ带宽的定制接收机，实现了对移频键控信号的远程接收，在48 Mbps的数据传输速率下，达到了−77.7dBm的灵敏度，误码率为10−8BER。对所有电子输入和输出进行的ESD测试证明，该可植入设备满足HBM Class-1B ESD标准。此外，对从每个I/O引脚传递到组织的最坏情况电荷密度的评估验证了设备在故障情况下的患者安全性。最后，整个装置的功能和可靠性已经在试验台上进行了测试，并在一年多的持续自由移动的猪和猴子动物试验中进一步得到了长期验证。
A 100-channel fully implantable wireless broadband neural recording system was developed. It features 100 parallel broadband (0.1 Hz–7.8 kHz) neural recording channels, a medical grade 200 mAh Li-ion battery recharged inductively at 150 kHz, and data telemetry using 3.2 GHz to 3.8 GHz FSK modulated wireless link for 48 Mbps Manchester encoded data. All active electronics are hermetically sealed in a titanium enclosure with a sapphire window for electromagnetic transparency. A custom, high-density configuration of 100 individual hermetic feedthrough pins enable connection to an intracortical neural recording microelectrode array. A 100 MHz bandwidth custom receiver was built to remotely receive the FSK signal and achieved −77.7 dBm sensitivity with 10−8 BER at 48 Mbps data rate. ESD testing on all the electronic inputs and outputs has proven that the implantable device satisfies the HBM Class-1B ESD Standard. In addition, the evaluation of the worst-case charge density delivered to the tissue from each I/O pin verifies the patient safety of the device in the event of failure. Finally, the functionality and reliability of the complete device has been tested on-bench and further validated chronically in ongoing freely moving swine and monkey animal trials for more than one year to date.