Fetal cardiovascular, endocrine, and fluid responses to atrial natriuretic factor infusion.
Fetal cardiovascular, endocrine, and fluid responses to atrial natriuretic factor infusion.
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胎儿心血管、内分泌和体液对心房钠尿因子输注的反应。
DOI：
10.1152/ajpregu.1989.257.3.r580
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Cheung,CY
中科院分区：
文献类型：
--
作者：
Brace,RA;Bayer,LA;Cheung,CY
本研究的目的是确定胎儿心钠素（ANF）的影响，并探讨胎儿心血管，内分泌和液体反应之间的相互作用ANF。在12只妊娠130 +/- 1（SE）天的长期插管胎羊中，以14-300 ng.min-1. kg-1静脉输注ANF 30 min。胎儿动脉血浆ANF浓度从输注前的163 +/- 13 pg/ml增加到5，410 pg/ml。ANF从循环中的清除率为122 +/- 28 ml.min-1. kg-1，半衰期为0.46 +/- 0.07 min。当血浆ANF大于2，000 pg/ml时，胎儿动脉压降低，静脉压一过性升高，心率不变。随着ANF浓度的升高，血浆精氨酸加压素（AVP）浓度和血浆肾素活性（PRA）升高，而去甲肾上腺素浓度不受影响。所有胎仔的胎血容量均减少，尿流量显著增加，但并非每个胎仔均如此。血液和尿液渗透压没有变化。在终止输注时，静脉压和尿流量降低至低于对照，而血容量和动脉压保持降低。血浆AVP浓度进一步增加，这是伴随着尿渗透压的增加。因此，ANF在胎儿中最一致的作用是血容量减少，这与尿流量变化无关。其他心血管，内分泌和液体反应ANF以及它们之间的相互作用似乎主要发生在超生理浓度，可能是继发于血容量的变化。（250字处删节）
The purpose of this study was to determine the effects of atrial natriuretic factor (ANF) in the fetus and to explore the interactions among the fetal cardiovascular, endocrine, and fluid responses to ANF. In 12 chronically catheterized fetal sheep at 130 +/- 1 (SE) days gestation, ANF was infused intravenously for 30 min at 14-300 ng.min-1.kg-1. Fetal arterial plasma ANF concentration increased by 174 to 5,410 pg/ml from a preinfusion value of 163 +/- 13 pg/ml. The clearance of ANF from the circulation was 122 +/- 28 ml.min-1.kg-1 and the half-life was 0.46 +/- 0.07 min. When plasma ANF was greater than 2,000 pg/ml, fetal arterial pressure decreased, venous pressure increased transiently, and heart rate was unchanged. Plasma arginine vasopressin (AVP) concentration and plasma renin activity (PRA) increased with high ANF concentrations, while norepinephrine concentrations were unaffected. Fetal blood volume decreased in all fetuses, and urine flow increased significantly but not in every fetus. Blood and urine osmolalities did not change. On terminating the infusion, venous pressure and urine flow decreased below control, while blood volume and arterial pressure remained reduced. Plasma AVP concentration increased further, and this was accompanied by an increase in urine osmolality. Thus the most consistent effect of ANF in the fetus was a reduction in blood volume, which was independent of urine flow changes. Other cardiovascular, endocrine, and fluid responses to ANF as well as interactions among them appeared to occur largely at supraphysiological concentrations and may be secondary to the changes in blood volume.(ABSTRACT TRUNCATED AT 250 WORDS)