Whole-body metabolic fate of branched-chain amino acids.
Whole-body metabolic fate of branched-chain amino acids.
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DOI：
10.1042/bcj20200686
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发表时间：
2021-02-26
影响因子：
4.1
通讯作者：
Arany, Zoltan
中科院分区：
文献类型：
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作者：
Blair, Megan C.;Neinast, Michael D.;Arany, Zoltan
支链氨基酸（BCAAs）的氧化在哺乳动物中受到严格调控。我们在这里审查的分布和全身BCAA氧化的调节。限速酶支链α-酮酸脱氢酶复合物的磷酸化和去磷酸化直接调节支链氨基酸的氧化，也存在其他各种间接调节机制。全身大部分组织都能够氧化BCAA，每个组织中氧化BCAA的通量受三个关键因素影响：1.相对于其他燃料，BCAA氧化的组织特异性偏好，2.组织内线粒体的总体氧化活性，以及3.总组织质量。BCAA氧化的扰动与许多疾病有关，强调了BCAA稳态在整体健康中的重要性。
Oxidation of branched-chain amino acids (BCAAs) is tightly regulated in mammals. We review here the distribution and regulation of whole-body BCAA oxidation. Phosphorylation and dephosphorylation of the rate-limiting enzyme, branched-chain α-ketoacid dehydrogenase complex directly regulates BCAA oxidation, and various other indirect mechanisms of regulation also exist. Most tissues throughout the body are capable of BCAA oxidation, and the flux of oxidative BCAA disposal in each tissue is influenced by three key factors: 1. tissue-specific preference for BCAA oxidation relative to other fuels, 2. the overall oxidative activity of mitochondria within a tissue, and 3. total tissue mass. Perturbations in BCAA oxidation have been implicated in many disease contexts, underscoring the importance of BCAA homeostasis in overall health.