Personality, lifestyle, and risk of cardiovascular disease and cancer:: follow-up of population based cohort
Personality, lifestyle, and risk of cardiovascular disease and cancer:: follow-up of population based cohort
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DOI：
10.1136/bmj.38833.479560.80
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发表时间：
2006-06-10
影响因子：
--
通讯作者：
Amelang, M
中科院分区：
文献类型：
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作者：
Stürmer, T;Hasselbach, P;Amelang, M
目的在一个大的队列研究中，研究人格测量与心血管疾病和癌症风险之间的关系。设计基于人群的队列随访。设置海德堡，德国。参与者5114名年龄在40-65岁的女性和男性，1992 - 5年。主要结果测量1992-5年通过几种标准化人格问卷评估的心理特征，与死亡原因（至2002- 2003年）或报告的心血管疾病和癌症发病率（经主治医生证实）有关。使用多变量考克斯比例风险models.Results估计合并发病率和死亡率的相对风险（和95%置信区间），根据五个重要的人格特质，在中位数随访8.5年，257名参与者死亡，72名参与者被诊断为心脏病发作，62中风，240癌症。（发病率和死亡率合计）。对疾病的高内控点与心肌梗死风险降低相关（校正相对风险增加1 SD = 0.75; 95%置信区间0.58 - 0.96）。时间紧迫性增加1 SD与癌症风险降低相关（校正相对风险0.83; 0.73至0.95）。其他主要的人格特质愤怒控制，精神病，抑郁症的症状，并没有一贯与心肌梗死，中风，或cancer.Conclusion内部控制点的疾病和时间紧迫性似乎与常见的慢性疾病的风险降低，可能是通过影响不可测的健康相关行为。评估的其他人格特征对心血管疾病和癌症没有重大影响。
Objective To study the relation between measures of personality and risk of cardiovascular disease and cancer in a large cohort.Design Follow-up of population based cohort.Setting Heidelberg, Germany.Participants 5114 women and men aged 40-65 in 1992-5.Main outcome measures Psychological traits assessed by several standardised personality questionnaires in 1992-5, related to cause of death (to 2002-3) or reported incidence of cardiovascular diseases and cancer (validated by treating doctors). Relative risks (and 95% confidence intervals) for combined morbidity and mortality according to five important personality traits were estimated using multivariable Cox proportional hazards models.Results During median follow-up of 8.5 years, 257 participants died and 72 participants were diagnosed with a heart attack, 62 with stroke, and 240 with cancer. (morbidity and mortality combined). A high internal locus of control over disease was associated with a decreased risk of myocardial infarction (adjusted relative risk for an increase of 1 SD = 0.75; 95% confidence interval 0.58 to 0.96). An increase of 1 SD in time urgency was associated with a decreased risk of cancer (adjusted relative risk 0.83; 0.73 to 0.95). Other major personality traits-anger control, psychoticism, and symptoms of depression-were not consistently associated with myocardial infarction, stroke, or cancer.Conclusion Internal locus of control over disease and time urgency seem to be associated with reduced risk for common chronic diseases, probably by affecting unmeasured health related behaviour. The other personality traits assessed had no major impact on cardiovascular disease and cancer.