Th17-associated cytokines as a therapeutic target for steroid-insensitive asthma.
Th17-associated cytokines as a therapeutic target for steroid-insensitive asthma.
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DOI：
10.1155/2013/609395
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发表时间：
2013
影响因子：
--
通讯作者：
Hizawa N
中科院分区：
文献类型：
--
作者：
Morishima Y;Ano S;Ishii Y;Ohtsuka S;Matsuyama M;Kawaguchi M;Hizawa N
类固醇不敏感性哮喘是一种罕见但有问题的气道疾病，即使接受类固醇治疗，也会出现持续症状、气流受限或复发性加重。由于目前激素不敏感性哮喘的治疗效果不理想，因此需要更好地了解其发病机制并开发新的靶向分子治疗。最近的研究表明，白细胞介素（IL）-17水平的增加，嗜酸性粒细胞和中性粒细胞浸润的严重哮喘的气道。IL-17是主要由辅助性T（Th）17细胞分泌的促炎细胞因子，并且对于在炎症部位诱导中性粒细胞募集和迁移是重要的。本文综述了Th 17细胞及其相关细胞因子在激素不敏感性哮喘中的发病机制，并探讨了以Th 17信号通路为靶点的新型治疗方案的前景。
Steroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies. Because of unsatisfactory results obtained from currently available therapies for steroid-insensitive asthma, a better understanding of its pathogenesis and the development of new targeted molecular therapies are warranted. Recent studies indicated that levels of interleukin (IL)-17 are increased and both eosinophils and neutrophils infiltrate the airways of severe asthmatics. IL-17 is a proinflammatory cytokine mainly secreted from helper T (Th) 17 cells and is important for the induction of neutrophil recruitment and migration at sites of inflammation. This review focuses on the pathogenetic role of Th17 cells and their associated cytokines in steroid-insensitive asthma and discusses the prospects of novel therapeutic options targeting the Th17 signaling pathway.
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影响因子：
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通讯作者：
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