HLA-B locus in Caucasian patients with carbamazepine hypersensitivity
HLA-B locus in Caucasian patients with carbamazepine hypersensitivity
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DOI：
10.2217/14622416.7.6.813
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发表时间：
2006-09-01
期刊：
影响因子：
2.1
通讯作者：
Pirmohamed, Munir
中科院分区：
文献类型：
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作者：
Alfirevic, Ana;Jorgensen, Andrea L.;Pirmohamed, Munir
背景：据报道，在中国患者中，人白细胞抗原(HLA)-8*1502与卡马西平（CBZ）诱导的史蒂文斯-约翰逊综合征（SJS）存在很强的药物遗传学关联。方法：对56例不同程度CBZ过敏的高加索患者和43例CBZ无不良反应的对照进行HLA-B等位基因分型。结果：所有患者（包括2例起疱性皮疹患者）均无HLA-B*1502等位基因阳性。HLA-B*0702等位基因可预防严重的CBZ超敏反应，但有待进一步研究。其次，HLA-B*0801与HLA-DR3、DQ2和TNF-308等位基因（在祖先8.1单倍型上）的相关性与我们之前的发现一致。结论：HLA-B*1502似乎不是高加索人群中所有形式的cbz诱导的超敏反应的标志。
Background: A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-8*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS). Methods: We have gencityped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects. Results: None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF-308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings. Conclusion: HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.