Nicotine's enhancing effects on responding maintained by conditioned reinforcers are reduced by pretreatment with mecamylamine, but not hexamethonium, in rats.
Nicotine's enhancing effects on responding maintained by conditioned reinforcers are reduced by pretreatment with mecamylamine, but not hexamethonium, in rats.
复制标题
在大鼠中，用美加明（而非六甲铵）预处理会降低尼古丁对条件强化物维持的反应的增强作用。
DOI：
10.1037/a0020601
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发表时间：
2010
影响因子：
2.3
通讯作者：
Dallery,Jesse
中科院分区：
文献类型：
--
作者：
Jones,Jeb;Raiff,BethanyR;Dallery,Jesse
几项研究表明，尼古丁增加了由条件反射维持的反应。我们评估了皮下注射0.3 mg/kg尼古丁和两种尼古丁拮抗剂对8只Long Evans大鼠的条件反射和初级反射维持的反应以及消退期间的反应的影响。在实验阶段的一个子集之前，给予美加明（一种中枢和外周烟碱拮抗剂）和六甲双铵（一种外周烟碱拮抗剂）。尼古丁选择性地增加由条件反射剂和美加明维持的反应，但不是六甲铵，减弱了这种作用。这些结果表明，尼古丁对条件反射维持的反应的增强作用在中枢神经系统中介导。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Several studies have indicated that nicotine increases responding maintained by conditioned reinforcers. We assessed the effects of subcutaneous injections of 0.3 mg/kg nicotine and two nicotinic antagonists on responding maintained by conditioned and primary reinforcers and responding during extinction in 8 Long Evans rats. Mecamylamine, a central and peripheral nicotinic antagonist, and hexamethonium, a peripheral nicotinic antagonist, were administered prior to a subset of the experimental sessions. Nicotine selectively increased responding maintained by conditioned reinforcers and mecamylamine, but not hexamethonium, attenuated this effect. These results suggest that nicotine's enhancing effect on responding maintained by conditioned reinforcers is mediated in the central nervous system.(PsycINFO Database Record (c) 2016 APA, all rights reserved)