ISOLATION AND STRUCTURE DETERMINATION OF ENZYMATICALLY FORMED STYRENE OXIDE GLUTATHIONE CONJUGATES
ISOLATION AND STRUCTURE DETERMINATION OF ENZYMATICALLY FORMED STYRENE OXIDE GLUTATHIONE CONJUGATES
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DOI：
10.1016/0009-2797(79)90134-0
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发表时间：
1979-01-01
影响因子：
5.1
通讯作者：
SALMONA, M
中科院分区：
文献类型：
--
作者：
PACHECKA, J;GARIBOLDI, P;SALMONA, M
当氧化苯乙烯与谷胱甘肽在大鼠肝胞质组分的存在下孵育时，形成2种缀合物。通过质谱、PMR分析和化学裂解进行的结构研究表明存在2种位置异构体，即，S-（1-苯基-2-羟乙基）谷胱甘肽和S-（2-苯基-2-羟乙基）谷胱甘肽，比例为60：40。
When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, 2 conjugates were formed. Structural investigation by mass spectrometry, PMR analysis and chemical fragmentation showed the presence of 2 positional isomers, i.e., S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in a ratio of 60:40.