The importance of toll-like receptor 2 polymorphisms in severe infections
The importance of toll-like receptor 2 polymorphisms in severe infections
复制标题
DOI：
10.1086/431990
复制
发表时间：
2005-11-15
影响因子：
11.8
通讯作者：
Mira, JP
中科院分区：
文献类型：
--
作者：
Texereau, J;Chiche, JD;Mira, JP
Toll样受体2（TLR2）是TLR家族的成员，其在针对多种微生物的先天性免疫应答中起核心作用。动物研究表明，TLR2基因敲除的小鼠更容易感染金黄色葡萄球菌和单核细胞增生李斯特菌引起的败血症、肺炎链球菌引起的脑膜炎和结核分枝杆菌感染，这表明功能性TLR2多态性可能会损害宿主对某些微生物病原体的反应。在人类中，TLR2外显子部分的2个多态性减弱受体信号传导，增加急性严重感染、结核病和麻风病的风险。由于革兰氏阳性菌已成为严重感染（包括败血性休克）的首要原因，因此了解TLR2功能改变或缺乏在感染性疾病发病机制中的作用可能有助于设计新的治疗策略，包括预防、药物干预和疫苗开发。
Toll-like receptor 2 (TLR2) is a member of the TLR family, which plays a central role in the innate immune response to a wide variety of microorganisms. Animal studies have shown that TLR2-knockout mice are more susceptible to septicemia due to Staphylococcus aureus and Listeria monocytogenes, meningitis due to Streptococcus pneumoniae, and infection with Mycobacterium tuberculosis, suggesting that functional TLR2 polymorphisms may impair host response to a certain spectrum of microbial pathogens. In humans, 2 polymorphisms in the exon part of TLR2, which attenuate receptor signaling, enhance the risk of acute severe infections, tuberculosis, and leprosy. Because gram-positive bacteria have became the first cause of severe infections, including septic shock, knowledge of the role that alteration or lack of TLR2 function plays in the pathogenesis of infectious diseases could contribute to the design of new therapeutic strategies, including prevention, pharmacological intervention, and vaccine development.