Dynamin and endocytosis.
Dynamin and endocytosis.
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DOI：
10.1016/s0955-0674(02)00347-2
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发表时间：
2002-08
影响因子：
7.5
通讯作者：
Sanja Sever
中科院分区：
文献类型：
--
作者：
Sanja Sever
GT3发动蛋白是内吞作用所必需的，但其作用机制仍不确定。其GT3结构域的结构，以及组装发动蛋白的结构，导致了理解其作用模式的结构基础的重大进展。新的数据比以往任何时候都更清楚地指向这种蛋白质在肌动蛋白细胞骨架，促分裂原活化蛋白激酶信号传导和细胞凋亡中的作用，这表明发动蛋白可能是一种信号转导GT3。
The GTPase dynamin is essential for endocytosis, but its mechanism of action remains uncertain. Structures of its GTPase domain, as well as that of assembled dynamin, have led to major advances in understanding the structural basis of its mode of action. Novel data point more clearly than ever towards a role for this protein in the actin cytoskeleton, mitogen-activated protein kinase signaling and apoptosis, suggesting that dynamin might be a signaling GTPase.