‘Keratolytic’ Properties of Benzoyl Peroxide and Retinoic Acid Resemble Salicylic Acid in Man
‘Keratolytic’ Properties of Benzoyl Peroxide and Retinoic Acid Resemble Salicylic Acid in Man
复制标题
过氧化苯甲酰和视黄酸的“角质层分离”特性类似于人体中的水杨酸
DOI：
--
复制
发表时间：
2006
影响因子：
2.7
通讯作者：
Howard I. Maibach
中科院分区：
文献类型：
--
作者：
J. M. Waller;Frank Dreher;S. Behnam;C. Ford;C. Lee;T. Tiet;Gerald D. Weinstein;Howard I. Maibach
目的：研究了维甲酸（RA）和过氧化苯甲酰（BP），在相似条件下比较了它们与水杨酸（SA）（一种公认的角质层溶解剂）的角质层溶解功效和水屏障破坏。患者/方法：本盲法研究纳入6名志愿者。在前臂掌侧标记11个随机试验部位，包括0时未处理皮肤、未封闭、封闭和溶剂对照3 h和6 h的部位，以及BP、RA和SA溶液各3 h和6 h的部位。在每个时间点，在5个测试网站的闭塞被删除，并chromorphin测量进行了超过30分钟。每个网站，然后进行25角质层（SC）胶带剥离。在每个部位最后一次剥离后1、5和30 min，进行TEWL测量。然后对来自胶带的SC进行定量蛋白质分析。结果与结论：3小时后，BP在破坏SC凝聚力方面比SA和RA显著更有效，表明BP除了其抗菌特性外，还是一种中度角质层溶解剂。6小时后，所有三种药物在角膜溶解中的效果相似。屏障破坏，通过TEWL测量，测量SC去除的深度。SA倾向于在表面表现出最大的角质层溶解功效，因此其在浅表疾病（如粉刺性痤疮）中的临床有效性，而BP在更深的水平上更有效，补充了其抗菌作用，使其能够治疗更深、更炎性的病变。所有药物均未显著影响皮肤红斑。这些技术提供了一个强大的和快速的测定在体内角质层溶解演示。
Objectives: Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. Patients/Methods:Six volunteers were included in this blinded study. Eleven randomized test sites were marked on the volar forearms, containing sites for untreated skin at time zero, unoccluded, occlusion, and vehicle controls for 3 and 6 h, and each of BP, RA, and SA solutions for 3 and 6 h. At each time point, occlusion at 5 of the test sites was removed, and chromameter measurements were performed over 30 min. Each site then underwent 25 stratum corneum (SC) tape strippings. At 1, 5, and 30 min after the last stripping at each site, TEWL measurements were performed. Quantitative protein analysis of the SC from the tapes was then performed. Results and Conclusion: After 3 h, BP was significantly more effective in disrupting SC cohesion than SA and RA, indicating BP is a moderate keratolytic agent in addition to its antimicrobial properties. After 6 h, all three agents were similarly effective in keratolysis. Barrier disruption, as measured by TEWL, paralleled depth of SC removal. SA tended to exhibit the greatest keratolytic efficacy superficially, hence its clinical effectiveness in superficial conditions such as comedonal acne, whereas BP was more effective at deeper levels, complimenting its antimicrobial effects and enabling it to treat deeper, more inflammatory lesions. None of the agents significantly affected skin erythema. These techniques provide a robust and rapid assay for in vivo keratolytic demonstration.
类视黄醇对表皮结构、分化和渗透性的影响。
DOI：
--
发表时间：
1981
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Elias,PM;Fritsch,PO;Lampe,M;Williams,ML;Brown,BE;Nemanic,M;Grayson,S
通讯作者：
Grayson,S