Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice
复制标题
金刚烷胺和利巴韦林气雾剂治疗小鼠甲型和乙型流感病毒感染
DOI：
10.1128/aac.17.4.642
复制
发表时间：
1980
影响因子：
4.9
通讯作者：
R. Couch
中科院分区：
文献类型：
--
作者：
S. Z. Wilson;V. Knight;P. Wyde;S. Drake;R. Couch
利巴韦林、金刚烷胺以及这两种药物在小颗粒气雾剂中联合给药对治疗小鼠甲型流感感染非常有效。接种后72、96和120 h开始处理，连续给药4天。随着治疗开始时间的延长，利巴韦林的有效性明显降低，但金刚烷胺的有效性没有降低。联合治疗反映了利巴韦林活性的丧失。肺中白细胞浸润和病毒滴度与治疗有效性呈负相关。接种后72小时治疗的B型流感病毒感染仅对利巴韦林有反应，如甲型流感病毒描述的标准所示。接种后72小时开始腹腔内给药的方案相当于气雾剂比气雾剂治疗提供更少的保护。
Ribavirin, amantadine, and the two drugs in combination given in small-particle aerosol were highly effective in the treatment of influenza A infection in mice. Treatment was started 72, 96, and 120 h after inoculation and was given continuously for 4 days. With increasing delay in start of treatment, there was a pronounced reduction in effectiveness of ribavirin but not in that of amantadine. The combination treatment reflected the loss of ribavirin activity. Leukocyte infiltration and virus titers in the lungs were inversely related to the effectiveness of treatment. Influenza B infection treated 72 h after inoculation responded only to ribavirin, as indicated by the criteria described for influenza A. Intraperitoneal administration of drug begun 72 h after inoculation in regimens equivalent to aerosol afforded less protection than aerosol treatment.