How Effective Were Lifestyle Interventions In Real-World Settings That Were Modeled On The Diabetes Prevention Program?
How Effective Were Lifestyle Interventions In Real-World Settings That Were Modeled On The Diabetes Prevention Program?
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DOI：
10.1377/hlthaff.2011.1009
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发表时间：
2012-01-01
期刊：
影响因子：
9.7
通讯作者：
Williamson, David F.
中科院分区：
文献类型：
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作者：
Ali, Mohammed K.;Echouffo-Tcheugui, Justin B.;Williamson, David F.
我们对28项美国研究进行了系统回顾和荟萃分析，这些研究应用了糖尿病预防计划的发现，这是一项临床试验，旨在测试生活方式干预对糖尿病高危人群的影响。干预后12个月的平均体重变化是从参与者的基线体重下降约4%。无论干预是由经过临床培训的专业人员还是外行教育者提供，体重变化都是相似的。其他分析仅限于17项研究，随访评估时间为9个月或更长，显示体重变化相似。每增加一次生活方式会议，体重减轻增加0.26个百分点。我们的结论是，与糖尿病预防相关的成本可以降低，而不牺牲有效性，使用非医务人员和激励更高的出席率在程序会议。
We conducted a systematic review and meta-analysis of twenty-eight US-based studies applying the findings of the Diabetes Prevention Program, a clinical trial that tested the effects of a lifestyle intervention for people at high risk for diabetes, in real-world settings. The average weight change at twelve months after the intervention was a loss of about 4 percent from participants' baseline weight. Change in weight was similar regardless of whether the intervention was delivered by clinically trained professionals or lay educators. Additional analyses limited to seventeen studies with a nine-month or greater follow-up assessment showed similar weight change. With every additional lifestyle session attended, weight loss increased by 0.26 percentage point. We conclude that costs associated with diabetes prevention can be lowered without sacrificing effectiveness, using nonmedical personnel and motivating higher attendance at program sessions.