A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis
A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis
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DOI：
10.1016/j.arcmed.2021.03.006
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发表时间：
2021-08-16
影响因子：
7.7
通讯作者：
Kobayashi, Hiroshi
中科院分区：
文献类型：
--
作者：
Imanaka, Shogo;Yamada, Yuki;Kobayashi, Hiroshi
背景。最近的研究集中在氧化应激的作用上，氧化应激可能涉及子宫内膜异位症的发生、进展和病理生理。研究的目的。本研究旨在通过同时测定铁相关化合物（总铁、血红素铁、游离铁、氧化血红蛋白[oxyHb]、高铁血红蛋白[metHb]和8-羟基-2-脱氧鸟苷[8-OHdG]）和抗氧化剂（胆红素、血红素加氧酶-1 [HO-1]和总抗氧化能力[TAC]）来研究子宫内膜异位症的氧化还原平衡。方法。本研究纳入236例经组织病理学证实的病例（子宫内膜异位症178例，非子宫内膜异位症58例）。囊肿液样本采集自日本柏原奈良医科大学妇科收治的手术患者。结果。两组患者诊断年龄（p < 0.001）、囊肿最大直径（p < 0.001）、CA125水平（p < 0.001）差异均有统计学意义。子宫内膜异位症患者的总铁、血红素铁、游离铁、甲氧麻黄酮和氧化血红蛋白明显高于非子宫内膜异位症患者。子宫内膜异位症患者的胆红素、HO-1和TAC均明显高于非子宫内膜异位症患者。在子宫内膜异位症中，总铁与HO-1呈正相关（r = 0.518, p = 0.001），而在非子宫内膜异位症中，无抗氧化剂与铁相关。铁和HO-1与年龄和肿瘤大小无关。结论。HO-1可能调节子宫内膜异位囊肿液中铁诱导的氧化应激的微妙平衡。(c) 2021年墨西哥社会安全研究所。Elsevier Inc.出版。版权所有。
Background. Recent studies have focused on the role of oxidative stress, which may be implicated in the development, progression, and pathophysiology of endometriosis. Aim of the study. The aim of this study is to investigate the redox balance of endometriosis by simultaneously measuring iron-related compounds (total iron, heme iron, free iron, oxyhemoglobin [oxyHb], methemoglobin [metHb] and 8-hydroxy-2-deoxy guanosine [8-OHdG]) and antioxidants (bilirubin, heme oxygenase-1 [HO-1] and total antioxidant capacity [TAC]). Methods. This study includes 236 histopathologically confirmed cases (178 cases of endometriosis and 58 cases of non-endometriosis). Cyst fluid samples were collected from patients admitted to the Department of Gynecology, Nara Medical University, Kashihara, Japan, for surgery. Results. Age at diagnosis ( p < 0.001), the maximum diameter of the cyst ( p < 0.001) and CA125 levels ( p < 0.001) differed significantly between the two groups. Total iron, heme iron, free iron, metHb, and oxyHb were markedly higher in endometriosis compared to non-endometriosis. Bilirubin, HO-1 and TAC were significantly higher in endometriosis patients compared with those from non-endometriosis patients. In endometriosis, total iron showed a positive correlation with HO-1 ( r , 0.518, p = 0.001), but there were no antioxidants that correlated with iron in non-endometriosis. Iron and HO-1 did not correlate with age or tumor size. Conclusions. HO-1 may regulate the delicate balance of iron-induced oxidative stress in endometriotic cyst fluid. (c) 2021 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.