Pathological and physiological high-frequency oscillations in focal human epilepsy
Pathological and physiological high-frequency oscillations in focal human epilepsy
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DOI：
10.1152/jn.00341.2013
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发表时间：
2013-10-01
影响因子：
2.5
通讯作者：
Worrell, Gregory
中科院分区：
文献类型：
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作者：
Matsumoto, Andrew;Brinkmann, Benjamin H.;Worrell, Gregory
高频振荡（HFO;伽马：40-100 Hz，纹波：100-200 Hz，快速纹波：250-500 Hz）已在健康和疾病中得到广泛研究。这些现象可以作为癫痫脑的生物标志物;然而，区分病理性和正常生理性HFO的手段是必不可少的。我们分类任务引起的生理HFO期间的HFO引起的视觉或运动任务，通过测量频率，持续时间，和频谱振幅的每个事件在单次试验的时间-频率谱，并将它们与病理HFO类似地测量。病理性HFO比生理性HFO具有更高的平均频谱振幅、更长的平均持续时间和更低的平均频率。在个体患者中，支持向量机分析正确地分类了病理性HFO，除一名患者外，所有患者的敏感性范围为70-98%，特异性>90%。在这个病人中，罕见的高振幅HFO观察到运动皮层运动任务开始之前。这一发现提出了一种可能性，即在癫痫脑中，生理诱导的伽马可以呈现出与病理性HFO中所见相似的更高光谱振幅。如果自动化和验证，该方法可以提供区分生理性HFO和病理性HFO以及改善致癫痫脑定位的步骤。
High-frequency oscillations (HFO; gamma: 40-100 Hz, ripples: 100-200 Hz, and fast ripples: 250-500 Hz) have been widely studied in health and disease. These phenomena may serve as biomarkers for epileptic brain; however, a means of differentiating between pathological and normal physiological HFO is essential. We categorized task-induced physiological HFO during periods of HFO induced by a visual or motor task by measuring frequency, duration, and spectral amplitude of each event in single trial time-frequency spectra and compared them to pathological HFO similarly measured. Pathological HFO had higher mean spectral amplitude, longer mean duration, and lower mean frequency than physiological-induced HFO. In individual patients, support vector machine analysis correctly classified pathological HFO with sensitivities ranging from 70-98% and specificities >90% in all but one patient. In this patient, infrequent high-amplitude HFO were observed in the motor cortex just before movement onset in the motor task. This finding raises the possibility that in epileptic brain physiological-induced gamma can assume higher spectral amplitudes similar to those seen in pathologic HFO. This method if automated and validated could provide a step towards differentiating physiological HFO from pathological HFO and improving localization of epileptogenic brain.