Reduced albumin levels and utilization of arteriovenous access in pediatric patients with systemic lupus erythematosus (SLE).
Reduced albumin levels and utilization of arteriovenous access in pediatric patients with systemic lupus erythematosus (SLE).
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系统性红斑狼疮 (SLE) 儿童患者的白蛋白水平和动静脉通路利用率降低。
DOI：
10.1007/s00467-007-0591-2
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Furth,SusanL
中科院分区：
文献类型：
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作者：
Sule,SangeetaD;Fadrowski,JeffreyJ;Fivush,BarbaraA;Gorman,Gregory;Furth,SusanL
系统性红斑狼疮 (SLE) 是一种自身免疫性疾病，影响美国五至一万名儿童。大量 SLE 儿童的肾脏疾病可能会发展为终末期肾病 (ESRD)，随后需要透析治疗。我们进行了一项横断面分析，比较了维持血液透析 (HD) 的 SLE 儿科患者与其他原因导致 ESRD 的儿科患者实现国家肾脏基金会/肾脏疾病结果质量倡议临床目标的情况。 2000-2004 项目年终末期肾病临床表现测量中确定了 97 名独特的 SLE 患者和两个对照组（1,823 名患有其他原因的 ESRD 的独特儿科患者和 694 名患有肾小球肾炎的儿科患者）。与两个对照组相比，SLE 患者年龄较大，以女性和黑人为主。与继发于其他原因的 HD 的儿科患者相比，继发于 SLE 的 HD 儿科患者不太可能达到白蛋白目标，并且更有可能使用血管导管。这些发现可能与维持 HD 的 SLE 儿科患者发病率和死亡率增加有关，值得进一步研究。
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects between five and ten thousand children in the USA. Kidney disease may progress to end-stage renal disease (ESRD) and subsequent need for dialysis therapy in a significant number of children with SLE. We performed a cross-sectional analysis comparing achievement of National Kidney Foundation/Kidney Disease Outcomes Quality Initiative clinical targets in pediatric patients with SLE maintained on hemodialysis (HD) to pediatric patients with other causes of ESRD. Ninety-seven unique SLE patients and two control groups—1,823 unique pediatric patients with other causes of ESRD and 694 pediatric patients with glomerulonephritis—were identified in the End Stage Renal Disease Clinical Performance Measures 2000–2004 Project Years. SLE patients were older, with a female and black race predominance compared with both control groups. Pediatric patients maintained on HD secondary to SLE were less likely to meet albumin targets and more likely to have vascular catheters than were pediatric patients on HD secondary to other causes. These findings may be associated with increased morbidity and mortality in pediatric patients with SLE maintained on HD and deserve further study.