Effects of reduced coronary flow on thallium-201 accumulation and release in an in vitro rat heart preparation.
Effects of reduced coronary flow on thallium-201 accumulation and release in an in vitro rat heart preparation.
复制标题
冠状动脉流量减少对体外大鼠心脏制剂中铊 201 积累和释放的影响。
DOI：
10.1016/s0002-9149(83)80150-7
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Fossel,ET
中科院分区：
文献类型：
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作者：
Goldhaber,SZ;Newell,JB;Ingwall,JS;Pohost,GM;Alpert,NM;Fossel,ET
为了研究心肌铊-201 （Tl-201）摄取、释放与冠状动脉血流减少之间的关系，取离体Langendorff大鼠心脏（n = 8），以生理（12 ml/min）至严重缺血（1.5 ml/min）的恒定流量灌注3小时；用闪烁探针监测铊的活度。每颗心脏用铊缓冲液灌注1小时，然后以相同流速用无铊缓冲液灌注2小时。4种流的累积曲线均为单指数型。然而，在无铊缓冲液冲洗2小时内的释放曲线显示出双指数结构。早期快速释放成分随冠状动脉血流减少而降低，后期缓释成分随血流变化不显著。这些数据表明，铊清除至少有两种成分：与冠状动脉血流相关的快速（可能是细胞外）成分和与冠状动脉血流无关的缓慢（可能是细胞内）成分。这些发现应该有助于更好地理解临床观察到的铊再分布。
To study the relation between myocardial thallium-201 (Tl-201) uptake, Tl-201 release, and reduced coronary flow, isolated Langendorff rat hearts (n = 8) were perfused for 3 hours at constant flows ranging from physiologic (12 ml/min) to severely ischemic (1.5 ml/min); thallium activity was monitored with a scintillation probe. Each heart was perfused for 1 hour with thallium buffer, followed by 2 hours with thallium-free buffer at the same flow rate. Accumulation curves for all 4 flows were monoexponential. However, release curves during the 2 hours of washout with thallium-free buffer demonstrated a biexponential configuration. The early fast release component decreased with reductions in coronary flow, and the later slow release component did not vary significantly with flow. These data show that thallium clearance has at least 2 components: a rapid (possibly extracellular) component related to coronary flow and a slow (possibly intracellular) component independent of coronary flow. These findings should be useful in providing a better understanding of thallium redistribution observed clinically.