Emerging investigator series: deposited particles and human lung lining fluid are dynamic, chemically-complex reservoirs leading to thirdhand smoke emissions and exposure
Emerging investigator series: deposited particles and human lung lining fluid are dynamic, chemically-complex reservoirs leading to thirdhand smoke emissions and exposure
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新兴研究者系列：沉积颗粒和人体肺内壁液体是动态的、化学复杂的储存库，导致三手烟排放和暴露
DOI：
10.1039/d1ea00107h
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wietzoreck, Marco
中科院分区：
文献类型：
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作者：
Sheu, Roger;Hass-Mitchell, Tori;Ringsdorf, Akima;Berkemeier, Thomas;Machesky, Jo;Edtbauer, Achim;Klüpfel, Thomas;Filippi, Alexander;Musa Bandowe, Benjamin A.;Wietzoreck, Marco
三手烟（THS）在以前吸烟的地方持续存在，并可被转移到非吸烟环境中，导致非吸烟者暴露。使用高分辨率质谱的实验室实验表明，沉积的颗粒物（PM）和烟雾暴露的替代肺衬液（LLF）是大量的，化学复杂的水库气相THS排放物，包括有害的空气污染物，多环芳烃化合物，和含氮/氧的物种。PM和LLF两者都是随着时间的推移而化学演变的持久的真实世界THS储库，并且可以充当用于运输和排放反应性污染物及其反应副产物（例如，丙烯醛）。沉积在衣服、家具、身体和/或呼吸道上的PM会在很长的使用寿命内释放挥发性至半挥发性气体，这些气体会重新分配到其他室内材料中，并增加其整体持久性。另一方面，LLF排气主要由挥发性有机化合物组成，其含量受其水溶解度的影响，并且它们在呼吸中的持续时间将通过在内部水库中的重新分布而延长，正如本研究中的多室模型所证实的那样。
Thirdhand smoke (THS) persists in locations where smoking previously occurred and can be transported into non-smoking environments, leading to non-smoker exposure. Laboratory experiments using high-resolution mass spectrometry demonstrate that deposited particulate matter (PM) and smoke-exposed surrogate lung lining fluid (LLF) are substantial, chemically-complex reservoirs of gas-phase THS emissions, including hazardous air pollutants, polycyclic aromatic compounds, and nitrogen/oxygen-containing species. Both PM and LLF are persistent real-world THS reservoirs that chemically evolve over time, and can act as vehicles for the transport and emission of reactive pollutants and their reaction byproducts (e.g., acrolein). Deposited PM on clothes, furnishings, bodies, and/or airways will emit volatile to semi-volatile gases over long lifetimes, which can re-partition to other indoor materials and increase their overall persistence. On the other hand, LLF off-gassing consists predominantly of volatile organic compounds in amounts influenced by their aqueous solubilities, and their persistence in breath will be prolonged by re-distribution across internal aqueous reservoirs, as corroborated by multicompartment modeling in this study.