Effects of repeated electroconvulsive seizures on spontaneous alternation behavior and locomotor activity in rats
Effects of repeated electroconvulsive seizures on spontaneous alternation behavior and locomotor activity in rats
复制标题
DOI：
10.1248/bpb.31.1928
复制
发表时间：
2008-10-01
影响因子：
2
通讯作者：
Araki, Hiroaki
中科院分区：
文献类型：
--
作者：
Hidaka, Noriaki;Suemaru, Katsuya;Araki, Hiroaki
癫痫患者的认知功能受损和行为异常的风险显著更高。本研究观察了反复电休克（ECS）诱发的癫痫发作对大鼠Y迷宫自发性改变行为和旷场自发性活动的影响。并检测了抗癫痫药物对大鼠的影响。ECS连续给药7天，最后一次给药后24 h进行Y-迷宫和旷场测试。反复电惊厥发作显著损害自发交替，增加自主活动。此外，这些行为的变化所引起的七个管理ECS持续至少28天。通过每日给药抑制ECS诱导的癫痫发作。苯妥英钠（120 mg/kg，腹腔注射？（i.p.）），苯巴比妥（60 mg/kg，i. p.）和丙戊酸盐（400 mg/kg，i. p.）消除了旷场试验中的运动过度活跃。Y-迷宫试验中受损的自发交替行为也受到苯妥英和丙戊酸盐给药的显著抑制。而苯巴比妥注射液对Y迷宫实验无明显改善作用。这些结果表明，通过苯妥英钠和丙戊酸盐注射抑制ECS诱导的癫痫发作可抑制自发交替和运动亢进受损的发展。
Epileptic patients are at a significantly, higher risk for impairments of cognitive function and behavioral abnormalities. In this study, we investigated the effect of repeated electroconvulsive shock (ECS)-induced seizures on the spontaneous alter nation behavior in a Y-maze test and the locomotor activity in an open-field test. and examined the effects of anti-epileptic drugs in rats. ECS was administered for seven consecutive days and the Y-maze and open-field tests were performed 24 h after the last ECS administration. The repeated electroconvulsive seizures significantly impaired the spontaneous alternation and increased the locomotor activity. Moreover, these behavioral changes induced by the seven administrations of ECS persisted for at least 28 d. The inhibition of the ECS-induced seizures through the daily. pretreatment of the phenytoin (120 mg/kg, intraperitoneally? (i.p.)), phenobarbital (60 mg/kg, i.p.) and valproate (400 mg/kg, i.p.) abolished the locomotor hyperactivity in the open-field test. The impaired spontaneous alternation behavior in the Y-maze test was also significantly, suppressed by the treatment with phenytoin and valproate. However, phenobarbital injection produced no significant ameliorating effect in the Y-maze test. These results suggest that the inhibition of ECS-induced seizures through phenytoin and valproate injections suppress the development of impairment of spontaneous alternation and the locomotor hyperativity.