Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes
Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes
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DOI：
10.2337/dc08-1856
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发表时间：
2009-05-01
期刊：
影响因子：
16.2
通讯作者：
Mazzone, Theodore
中科院分区：
文献类型：
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作者：
Sam, Susan;Haffner, Steven;Mazzone, Theodore
目的-内脏脂肪组织（VAT）和皮下脂肪组织（SAT）都与非糖尿病人群的全身炎症有关。我们在一大群特征明确的 2 型糖尿病受试者中检查了 VAT 和 SAT 与全身炎症标志物之间的关系。 研究设计和方法 - 芝加哥（使用吡格列酮测量动脉粥样硬化中的颈动脉内膜中层厚度）研究队列中的 382 名 2 型糖尿病受试者接受了腹部计算机断层扫描以确定 SAT 和 VAT 分布。获得空腹血液用于测量炎症标志物。使用针对年龄、性别、糖尿病治疗、糖尿病病程、吸烟、他汀类药物使用和 A1C 进行调整的回归模型检查炎症标志物与 BMI、SAT 和 VAT 之间的关系。结果 - 在调整 BMI 之前，VAT 与 CRP、单核细胞趋化蛋白 (MCP)、细胞内粘附分子 (ICAM)-1 和纤溶酶原激活剂抑制剂 1 型 (PAI-1) 抗原呈正相关。调整 BMI 后，与 CRP 的关系消失，但与 MCP (P < 0.01)、PAI-1 (P < 0.0001)、ICAM-1 (P < 0.01)、血管细胞粘附分子 (P = 0.01) 呈明显正相关。即使在调整增值税和 SAT 后，BMI 仍与 CRP (P < 0.0001) 和 IL-6 (P < 0.01) 呈正相关。调整 BMI 后，SAT 与任何炎症标志物均无关。结论 - 在这一大群 2 型糖尿病受试者中，BMI 与 CRP 和 IL-6 水平的相关性最强。 SAT 与全身炎症标志物无关。 VAT 库的大小提供了除 BMI 提供的关于与血管壁重塑和凝血密切相关的炎症标志物的信息之外的信息。我们的研究结果表明，脂肪组织分布仍然是 2 型糖尿病全身炎症的重要决定因素。
OBJECTIVE- Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) have been linked to systemic inflammation in nondiabetic cohorts. We examined the relationships between VAT and SAT and systemic inflammatory markers in a large well-characterized cohort of subjects With type 2 diabetes.RESEARCH DESIGN AND METHODS- Three hundred eighty-two subjects with type 2 diabetes in the CHICAGO (Carotid Intima-Media Thickness in Atherosclerosis Using Pioglitazone) study cohort underwent abdominal Computed tomography to determine SAT and VAT distribution. Fasting blood was obtained for measurement of inflammatory markers. The relationships between inflammatory markers and BMI, SAT, and VAT were examined using regression models adjusted for age, sex, diabetes treatment, duration of diabetes, smoking, statin use, and A1C.RESULTS- VAT was positively related to CRP, monocyte chemoattractant protein (MCP), intracellular adhesion molecule (ICAM)-1, and plasminogen activator inhibitor type 1 (PAI-1) antigen before adjustment for BMI. After adjustment for BMI, the relationship to CRP was lost but Positive associations with MCP (P < 0.01), PAI-1 (P < 0.0001), ICAM-1 (P < 0.01), an vascular cell adhesion molecule (P = 0.01) were evident. BMI Was Positively related to CRP (P < 0.0001) and IL-6 (P < 0.01) even after adjustment for VAT and SAT. SAT was not related to any inflammatory marker after adjustment for BMI.CONCLUSIONS- In this large group of subjects with type 2 diabetes, BMI was Most strongly associated with CRP and IL-6 levels. SAT was not associated with markers of systemic inflammation. The Size Of the VAT depot provided information additional to that provided by BMI regarding inflammatory markers that are strongly related to vascular wall remodeling and coagulation. Our findings Suggest that adipose tissue distribution remains an important determinant of systemic inflammation in type 2 diabetes.