The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting
The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting
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DOI：
10.1016/j.physbeh.2012.06.002
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发表时间：
2012-08-20
影响因子：
2.9
通讯作者：
Funahashi, Makoto
中科院分区：
文献类型：
--
作者：
Shinpo, Keisuke;Hirai, Yoshiyuki;Funahashi, Makoto
最后区是室周器官之一，缺乏血脑屏障，并且众所周知是呕吐的化学感受器触发区。最后区神经元对血浆中携带的催吐化学物质敏感。我们以前的研究表明存在3种类型的神经元，其特征在于在每种细胞类型中表达不同的离子通道，但参与恶心和/或呕吐诱导的最后区神经元的类型仍不清楚。为了阐明表达超极化激活阳离子通道（H通道）的最多细胞在诱导恶心和/或呕吐中的作用，我们研究了ZD 7288（一种H通道抑制剂）对阿朴吗啡诱导的条件性味觉厌恶（CTA）对糖精和最后区c-Fos表达的影响。我们发现ZD 7288抑制CTA的获得，并降低阿朴吗啡诱导的最后区c-Fos表达，表明表达H通道的细胞参与了恶心和/或呕吐的诱导。最后，我们讨论了表达H通道的细胞在恶心和/或呕吐机制中的作用。(C)2012 Elsevier Inc. All rights reserved.
The area postrema is one of the circumventricular organs, lacks a blood-brain barrier, and is well known as the chemoreceptor trigger zone for emesis. Area postrema neurons are sensitive to emetic chemical substances carried in the blood plasma. Our previous study demonstrated the presence of 3 types of neurons characterized by different ion channels expressed in each cell type, but the type or types of area postrema neurons involved in the induction of nausea and/or emesis have remained unclear. To clarify the role of the most populous cells, which express the hyperpolarization-activated cation channel (H-channel), in induction of nausea and/or emesis, we investigated the effects of ZD7288 (an H-channel inhibitor) on apomorphine-induced conditioned taste aversion (CTA) to saccharin and c-Fos expression in the area postrema. We found that ZD7288 inhibited the acquisition of CTA and reduced apomorphine-induced c-Fos expression in the area postrema, indicating the involvement of the cells expressing H-channels in the induction of nausea and/or emesis. Finally, we discuss the role of cells expressing H-channels in the mechanism of nausea and/or vomiting. (C) 2012 Elsevier Inc. All rights reserved.