Localization of stereo-electroencephalography signals using a finite difference complete electrode model.
Localization of stereo-electroencephalography signals using a finite difference complete electrode model.
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使用有限差分完整电极模型定位立体脑电图信号。
DOI：
10.1109/embc.2017.8037636
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Warfield,SimonK
中科院分区：
文献类型：
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作者：
Hyde,DamonE;Tomas-Fernandez,Xavier;Stone,ScelligS;Peters,Jurriaan;Warfield,SimonK
癫痫的外科干预旨在通过切除导致癫痫发作的组织来消除难治性患者的癫痫发作。立体脑电图（sEEG）使用通过颅骨中的小孔立体定向植入的窄多触点电极提供高度准确但侵入性的电生理测量。然而，sEEG测量的三维性质使得观察到的癫痫发作难以与物理皮层区域相关联。来自sEEG测量的三维源定位可以改善对该数据的解释，但是与来自头皮EEG的定位相比需要更准确的建模。在这里，我们提出了一种有限差分方法，该方法对每个电极的接触阻抗和物理范围（所谓的完整电极模型）进行建模，以从sEEG测量中定位脑电活动。我们将此模型应用于难治性癫痫患者的MRI和CT，并重建与sEEG中观察到的多种类型的复发性发作棘波相关的活动。独立地，神经外科医生切除了临床确定的癫痫发作病灶，形成切除腔，并使患者无癫痫发作。我们的定位将癫痫发作病灶定位在枕叶的病灶区域，完全包含在切除区域内。
Surgical intervention in epilepsy aims to eliminate seizures in refractory patients by resecting the tissue responsible for seizure onset. Stereo-electroencephalography (sEEG) provides highly accurate but invasive electrophysiological measurements using narrow multi-contact electrodes implanted stereotactically through small holes in the skull. However, the three dimensional nature of sEEG measurements make observed seizure onsets difficult to associate with physical cortical regions. Three dimensional source localization from sEEG measurements can improve the interpretation of this data, but requires more accurate modeling as compared to localization from scalp EEG. Here, we present a finite difference approach that models the contact impedance and physical extent of each electrode (the so-called complete electrode model), to localize brain electrical activity from sEEG measurements. We applied this model to MRI and CT in a patient with intractable epilepsy, and reconstructed activity associated with multiple types of recurrent ictal spikes observed in sEEG. Independently, the neurosurgeon resected the clinically determined seizure focus, creating a resection cavity, and rendering the patient free of seizures. Our localization placed the seizure focus at a focal region in the occipital lobe, entirely contained within the resection region.