Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
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DOI：
10.1088/0031-9155/55/22/008
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发表时间：
2010-11-21
影响因子：
3.5
通讯作者：
Noda, Koji
中科院分区：
文献类型：
--
作者：
Inaniwa, Taku;Furukawa, Takuji;Noda, Koji
介绍了一种基于改进的微剂量学动力学模型(MKM)的治疗离子束混合辐射场相对生物效应的计算方法。此外，我们还展示了将改进的MKM集成到扫描碳束的治疗计划系统中的过程。通过这一程序，该模型完全集成到我们的治疗计划系统的研究版本中。为了解释细胞系放射敏感性的变化，我们从当前细胞的一条存活曲线测量了三个MKM参数中的一个，并将该参数用于生物优化。在千叶重离子医疗加速器(HIMAC)上用扫描碳束照射人涎腺肿瘤细胞，并将测量的深度-存活曲线与修正的MKM预测存活曲线进行比较。这两条曲线的一致性很好地证明了所提出的方法是计算离子辐照治疗计划中生物效应的候选方法。
We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam. With this procedure, the model is fully integrated into our research version of the treatment planning system. To account for the change in radiosensitivity of a cell line, we measured one of the three MKM parameters from a single survival curve of the current cells and used the parameter in biological optimization. Irradiation of human salivary gland tumor cells was performed with a scanned carbon beam in the Heavy Ion Medical Accelerator in Chiba (HIMAC), and we then compared the measured depth-survival curve with the modified MKM predicted survival curve. Good agreement between the two curves proves that the proposed method is a candidate for calculating the biological effects in treatment planning for ion irradiation.