CHARACTERISTICS OF BRONCHIAL CLEARANCE IN HUMANS AND EFFECTS OF CIGARETTE SMOKING
CHARACTERISTICS OF BRONCHIAL CLEARANCE IN HUMANS AND EFFECTS OF CIGARETTE SMOKING
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DOI：
10.1080/00039896.1969.10665482
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发表时间：
1969-01-01
期刊：
影响因子：
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通讯作者：
BRISCOE, W
中科院分区：
文献类型：
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作者：
ALBERT, RE;LIPPMANN, M;BRISCOE, W
在36名受试者的117次实验中研究了直径为0.8μ至7.9μ的放射性单分散氧化铁气溶胶的清除。在大多数正常受试者中，有两个离散的支气管清除期，第一个通常在吸入后1 - 2小时内完成，第二个在吸入后4 - 10小时内完成。在每个阶段清除的分数强烈依赖于吸入颗粒的大小，较大颗粒的第一阶段清除率较高。支气管清除率表示为完成50%至90%支气管清除所需的时间。根据迄今为止积累的有限数据，14个吸烟者中有8个、3个前铀矿工人中有3个、2个肺气肿病例中有2个的支气管清除功能受损。
The clearance of radioactive monodisperse ferric oxide aerosols ranging in diameter from 0.8μto 7.9μwas studied in a total of 117 experiments on 36 subjects. In most normal subjects there were two discrete periods of bronchial clearance, with the first usually completed within one to two hours, and the second within four to ten hours after inhalation. The fraction cleared in each phase was strongly dependent on the size of the inhaled particles, with more first phase clearance for larger particles. The rates of bronchial clearance were expressed in terms of the time required for completion of 50% to 90% bronchial clearance. On the basis of the limited data thus far accumulated, bronchial clearance was impaired in eight out of fourteen cigarette smokers, three out of three former uranium miners, and two out of two emphysema cases.