6 WIDESPREAD BACTERIAL CLONES AMONG ESCHERICHIA-COLI K1 ISOLATES
6 WIDESPREAD BACTERIAL CLONES AMONG ESCHERICHIA-COLI K1 ISOLATES
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DOI：
10.1128/iai.39.1.315-335.1983
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
SILVER, RP
中科院分区：
文献类型：
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作者：
ACHTMAN, M;MERCER, A;SILVER, RP
E.大肠杆菌分离株的特征包括血清型、主要外膜蛋白的电泳迁移、代谢特性、溶血素或大肠杆菌素或两者的产生以及质粒含量。这些特性在E.大肠杆菌菌株的荚膜类型K1，K5，K92和K100和非包囊分离物。来自美国和欧洲的234种细菌菌株是最近或早在1941年从健康或患病个体中分离出来的。无论来源如何，大多数O7：K1、O16：K1和O75：K100分离株都可以被分配到3个独特的、细菌型特异性的组，这被解释为代表3个细菌克隆。在O18：K1和O18：K5分离株中分别识别出两个细菌（亚）克隆，在O1：K1分离株中识别出另外2个不同的克隆。这些结果的流行病学分析和毒力的影响进行了讨论。
Variable properties among E. coli isolates include serotype, electrophoretic migration of major outer membrane proteins, metabolic properties, production of hemolysin or colicin or both, and plasmid content. These characteristics were compared in E. coli strains of capsular types K1, K5, K92 and K100 and in non-encapsulated isolates. The 234 bacterial strains from the USA and Europe studied were isolated from healthy or diseased individuals recently or as long ago as 1941. Regardless of source, most O7:K1, O16:K1 and O75:K100 isolates could be assigned to 3 unique, serotype-specific groups, which were interpreted as representing 3 bacterial clones. Two bacterial (sub)clones each were discerned among the O18:K1 and O18:K5 isolates and 2 further, distinct clones were discerned among the O1:K1 isolates. The implications of these results for epidemiological analyses and for virulence are discussed.