Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations.
Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations.
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DOI：
10.1155/2016/8603263
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发表时间：
2016
影响因子：
--
通讯作者：
Valle D
中科院分区：
文献类型：
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作者：
Bellinato DF;Viana-Medeiros PF;Araújo SC;Martins AJ;Lima JB;Valle D
在公共卫生领域，杀虫剂仍在很大程度上用于控制病媒。在巴西，有机磷(OP)和拟除虫菊酯(PY)多年来一直用于防治埃及伊蚊。自2009年以来，昆虫生长调节剂(IGR)也被用于控制幼虫。我们量化了2010至2012年间从全国12个城市采集的埃及伊蚊样本对敌敌畏(OP)、溴氰菊酯(PY)和灭幼脲(IGR)的抗药性。几乎所有种群对神经毒性杀虫剂都表现出较高的抗性水平：对敌敌畏的RR95在4.0~27.1之间，对溴氰菊酯的RR95最低为13.1，值大于70.0。相反，所有样品都对除虫脲敏感(RR95；lt；2.3)。对幼虫和成虫进行的生化测试排除了OP靶标乙酰胆碱酯酶的参与，并确认了解毒酶酯酶、混合功能氧化酶和谷胱甘肽-S转移酶的参与。对所取得的结果进行了讨论，同时考虑到公共化学品控制部分和被评估市镇在登革热流行季节期间国内杀虫剂使用量的增加。
Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethrin (PY), and diflubenzuron (IGR) of A. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. High levels of resistance to neurotoxic insecticides were detected in almost all populations: RR95 to temephos varied between 4.0 and 27.1; the lowest RR95 to deltamethrin was 13.1, and values higher than 70.0 were found. In contrast, all samples were susceptible to diflubenzuron (RR95 < 2.3). Biochemical tests performed with larvae and adults discarded the participation of acetylcholinesterase, the OP target, and confirmed involvement of the detoxifying enzymes esterases, mixed function oxidases, and glutathione-S-transferases. The results obtained were discussed taking into account the public chemical control component and the increase in the domestic use of insecticides during dengue epidemic seasons in the evaluated municipalities.