Estrogen and Androgen Target Cells in the Brain of Fishes, Reptiles and Birds: Phylogeny and Ontogeny
Estrogen and Androgen Target Cells in the Brain of Fishes, Reptiles and Birds: Phylogeny and Ontogeny
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鱼类、爬行动物和鸟类大脑中的雌激素和雄激素靶细胞：系统发育和个体发育
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发表时间：
1978
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通讯作者：
Martinez
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作者：
Ye Soon Kim;W. Stumpf;M. Sar;M. Christine;Martinez
用解冻挂片放射自显影技术研究了~3H-雌二醇在金鱼、对虾、蜥蜴、龟和环鸽前脑内的细胞和亚细胞分布。雌激素靶细胞在这些非哺乳动物物种中的地形分布符合我们实验室早些时候为哺乳动物建立的一般模式。在所有被研究的非哺乳动物中，雌激素靶细胞存在于视前隔、中央下丘脑和丘脑区域。虽然在鸟类和爬行动物中存在雌激素靶细胞的异地分布，但在硬骨鱼中似乎没有。大脑进化的差异可能是原因之一。正如在鸡胚胎中观察到的那样，这种端脑类固醇靶点的系统发育延迟似乎与个体发育延迟平行：早期胚胎出现在视前区和中央下丘脑区域的雌激素摄取(受体)，以及较晚出现在杏仁核中的雌激素受体。在鸽子和蜥蜴的前脑中，雄激素的分布与雌激素的分布是重叠的，但有一些例外。
The cellular and subcellular distribution of 3H estradiol in the forebrain of goldfish, platyfish, lizard, turtle, and ring dove was studied by thaw-mount autoradiography. The topographic distribution of estrogen target cells in these non-mammalian species corresponds to the general pattern established earlier in our laboratory for mammals. In all non-mammalians studied, accumulations of estrogen target cells exist in preoptic-septal, central hypothalamic and thalamic areas. While allocortical distribution of estrogen target cells is present in the avian and reptilian species, it appears to be absent in the teleosts. Differences in brain evolution probably account for it. This phylogenetically delayed acquisition of telencephalic steroid target sites seems paralleled by an ontogenetic delay, as observed in the chick embryo: early embryonic appearance of estrogen uptake (receptors) in preoptic and central hypothalamic regions and late appearance of estrogen receptors in the amygdala. Androgen distribution in the forebrain of the dove and lizard overlaps with the estrogen distribution with some exceptions.