Retinal lesions in subacute sclerosing panencephalitis.
Retinal lesions in subacute sclerosing panencephalitis.
复制标题
亚急性硬化性全脑炎的视网膜病变。
DOI：
--
复制
发表时间：
1970
期刊：
影响因子：
--
通讯作者：
J. DePeralta
中科院分区：
文献类型：
--
作者：
D. A. Nelson;A. Weiner;M. Yanoff;J. DePeralta
两名十几岁的女孩死于进行性神经系统疾病，尸检诊断为亚急性硬化性全脑炎。一名患者的主要症状是视力丧失，另一名患者则是运动不能性癫痫发作。1例患者一只眼丧失中心视力，然后另一只眼丧失中心视力。检眼镜检查发现黄斑病变，包括水肿，色素沉着和孔形成。另一名患者在患病期间没有视力问题，除了视盘有些苍白外，在生活中没有发现视网膜病变。然而，在尸检时，注意到视网膜病变。这两名患者的大脑和视网膜的神经元细胞中显示出大量的包涵体。据我们所知，包涵体以前没有被证明在视网膜病变的患者与这种疾病。
Two teen-age girls died from a progressive neurological disease diagnosed at autopsy as subacute sclerosing panencephalitis. The presenting symptom in one patient was loss of vision; in the other, akinetic seizures. One patient lost central vision in one eye, then in the other. Ophthalmoscopic examination revealed a macular lesion consisting of edema, pigmentation, and hole formation. The other patient did not have visual complaints during the illness, and retinal lesions were not demonstrated during life, except for some pallor of the optic discs. At autopsy, however, lesions of the retinas were noted. Both patients showed numerous inclusion bodies in the brain and neuronal cells of the retinas. To our knowledge, inclusion bodies previously have not been demonstrated in retinal lesions of patients with this disease.