Metabolic Inputs into the Epigenome.
Metabolic Inputs into the Epigenome.
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DOI：
10.1016/j.cmet.2017.02.003
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发表时间：
2017-03
期刊：
影响因子：
29
通讯作者：
Upasna Sharma;O. Rando
中科院分区：
文献类型：
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作者：
Upasna Sharma;O. Rando
除了基因组序列--表观遗传信息--外，许多分子途径在将信息从一代传给下一代的过程中发挥着关键作用。然而，所谓的表观遗传标记也影响着各种各样的生理过程，即使在不会导致可遗传后果的情况下也是如此。也许不可避免的是，表观遗传调控机制对代谢信号高度响应，例如，中央代谢物是催化在组蛋白、DNA和RNA上沉积共价修饰的酶的底物。有趣的是，除了代谢物对体细胞生物调节的影响外，过去十年来的多项研究表明，祖先的营养可以改变后代的代谢表型，这引发了代谢如何调节生殖细胞表观基因组的问题。在这里，我们回顾了新陈代谢和表观遗传修饰之间的广泛联系，无论是在体细胞还是在种系中。
A number of molecular pathways play key roles in transmitting information in addition to the genomic sequence—epigenetic information—from one generation to the next. However, so-called epigenetic marks also impact an enormous variety of physiological processes, even under circumstances that do not result in heritable consequences. Perhaps inevitably, the epigenetic regulatory machinery is highly responsive to metabolic cues, as, for example, central metabolites are the substrates for the enzymes that catalyze the deposition of covalent modifications on histones, DNA, and RNA. Interestingly, in addition to the effects that metabolites exert over biological regulation in somatic cells, over the past decade multiple studies have shown that ancestral nutrition can alter the metabolic phenotype of offspring, raising the question of how metabolism regulates the epigenome of germ cells. Here, we review the widespread links between metabolism and epigenetic modifications, both in somatic cells and in the germline.