Human cortical EEG rythms during long-term episodic memory task. A high-resolution EEG study of the HERA model
Human cortical EEG rythms during long-term episodic memory task. A high-resolution EEG study of the HERA model
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DOI：
10.1016/j.neuroimage.2003.11.023
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Rossini, PM
中科院分区：
文献类型：
--
作者：
Babiloni, C;Babiloni, F;Rossini, PM
最近许多关于情景记忆的神经影像学研究表明，前额叶参与的不对称性，左前额叶皮质比右前额叶皮质更多地参与编码，右前额叶皮质比左前额叶皮质更多地参与提取（半球编码和提取不对称性，或HERA模型）。在这项高分辨率脑电图（EEG）研究中，我们研究了视觉情景记忆（识别）任务期间的脑节律性。在包括编码（ENC）和提取（RET）阶段的视觉空间长时情景记忆任务中，研究了θ（4-6 Hz）、α（6-12 Hz）和γ（28-48 Hz）振荡。在ENC阶段，25个代表建筑物内部（“室内”）的数字与25个代表景观（“景观”）的数字随机混合。受试者的反应是在左（“室内”）或右（“景观”）鼠标按钮。在RET阶段（1小时后），25个数字代表以前提出的“室内”的图片（“测试”）随机与25个数字代表新的“室内”（“干扰”）。同样，需要小鼠的响应。θ和α脑电图结果显示额叶节律无变化。与此相反，HERA预测的不对称性只适合EEG伽马响应，但仅在后顶叶区域。ENC相位与左侧顶叶皮层的γ EEG振荡相关。之后，PET阶段与主要在右顶叶皮层的伽马EEG振荡相关。因此，在非预期位置观察到预测的HERA不对称性。这种差异可能是由于不同的敏感性神经成像方法选择的组成部分的认知处理。伽马反应和知觉之间的严格关系表明，长期记忆的提取过程深深地影响了对储存材料的感官表征。(C)2004年爱思唯尔公司All rights reserved.
Many recent neuroimaging studies of episodic memory have indicated an asymmetry in prefrontal involvement with the left prefrontal cortex more involved than the right in encoding, the right more than the left in retrieval (hemispheric encoding and retrieval asymmetry, or HERA model). In this electroencephalographic (EEG) high-resolution study, we studied brain rhythmicity during a visual episodic memory (recognition) task. The theta (4-6 Hz), alpha (6-12 Hz) and gamma (28-48 Hz) oscillations were investigated during a visuospatial long-term episodic memory task including an encoding (ENC) and retrieval (RET) phases. During the ENC phase, 25 figures representing interiors of buildings ("indoor") were randomly intermingled with 25 figures representing landscapes ("landscapes"). Subject's response was given at left ("indoor") or right ("landscapes") mouse button. During the RET phase (I h later), 25 figures representing previously presented "indoor" pictures ("tests") were randomly intermingled with 25 figures representing novel "indoor" ("distractors"). Again, a mouse response was required. Theta and alpha EEG results showed no change of frontal rhythmicity. In contrast, the HERA prediction of asymmetry was fitted only by EEG gamma responses, but only in the posterior parietal areas. The ENC phase was associated with gamma EEG oscillations over left parietal cortex. Afterward, the PET phase was associated with gamma EEG oscillations predominantly over right parietal cortex. The predicted HERA asymmetry was thus observed in an unexpected location. This discrepancy may be due to the differential sensitivity of neuroimaging methods to selected components of cognitive processing. The strict relation between gamma response and perception suggests that retrieval processes of long-term memory deeply impinged upon sensory representation of the stored material. (C) 2004 Elsevier Inc. All rights reserved.