Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study
Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study
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DOI：
10.3892/etm.2018.7134
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发表时间：
2019-03-01
影响因子：
2.7
通讯作者：
Chen, Zhiqi
中科院分区：
文献类型：
--
作者：
Li, Mu;Ke, Manlin;Chen, Zhiqi
本研究旨在探讨中央视觉通路弥散张量成像（DTI）参数和外侧膝状核（LGN）大小在原发性开角型青光眼（POAG）诊断中的应用价值。为了验证这一点，24名POAG患者和24名年龄和性别匹配的对照组进行了3.0特斯拉磁共振成像检查，包括DTI和LGN结构成像。生成受试者工作特征（ROC）曲线，并确定Spearman相关系数。结果表明，在鉴别POAG患者与健康对照时，视束分数各向异性（FA）值的截断值为0.412，ROC曲线下面积为0.931，灵敏度最高（79.2%），特异度最高（89.6%）。视束FA值和光辐射值与LGN大小有显著相关性，而平均扩散系数值与LGN大小无显著相关性。综上所述，视神经束FA值可作为青光眼评价的一种敏感、可靠的生物标志物。
The aim of the present study was to investigate the utility of diffusion tensor imaging (DTI) parameters of the central visual pathway and the size of the lateral geniculate nucleus (LGN) in the diagnosis of primary open-angle glaucoma (POAG). To test this, 24 POAG patients and 24 age- and gender-matched controls underwent 3.0 Tesla magnetic resonance imaging examinations, including DTI and LGN structural imaging. Receiver operating characteristic (ROC) curves were generated and Spearman's correlation coefficients were also determined. The results indicated that regarding the discrimination of POAG patients from healthy controls, the fractional anisotropy (FA) values of the optic tract, at a cutoff of 0.412, with an area under the ROC curve of 0.931, exhibited the highest sensitivity (79.2%) and specificity (89.6%). The FA values of the optic tract and the optic radiation were significantly correlated with LGN size, while the mean diffusivity values were not. In conclusion, the FA value of the optic tract may be a sensitive and reliable biomarker for glaucoma evaluation.