A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders
A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders
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DOI：
10.1046/j.1399-5618.2003.00091.x
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发表时间：
2004-02-01
影响因子：
5.4
通讯作者：
Young, LT
中科院分区：
文献类型：
--
作者：
Joffe, RT;MacQueen, GM;Young, LT
背景资料：最近有一个认识，双相情感障碍患者花了相当长的一段时间与轻微或亚综合征的情绪症状躁狂和抑郁。本研究探讨了时间花在轻微和亚综合征的情绪状态，以及躁狂和抑郁症的特点，以及双相I和II患者的前瞻性随访平均为three years.Method：详细的生活图表数据，从138例双相情感障碍。根据严格定义的标准，情绪状态被描述为情绪正常、亚综合征、轻微或严重的情感发作。花在这些情绪状态在后续的时间量examined.Results：在总样本中，每个双相亚型内的患者花了大约一半的时间euthymic。剩下的时间是在不同严重程度的情绪状态中度过的。然而，大部分时间都花在轻微和亚综合征症状上，包括躁狂和抑郁。双相I型患者与双相II型患者的不同之处在于，亚综合征、轻微症状和躁狂症状花费的时间明显更多。两组之间的抑郁症状所花费的时间没有差异：双相情感障碍患者花了很大比例的时间与抑郁或躁狂症状的优势是轻微或亚综合征。通过建立指南，明确列出减少双相情感障碍亚综合征症状持续时间的适当策略，可以提高对双相情感障碍亚阈值症状的认识和对此类症状的治疗。
Background: There is a recent appreciation that patients with bipolar disorder spend a substantial period of time with minor or subsyndromal mood symptoms both manic and depressive. This study examined time spent in minor and subsyndromal mood states as well as with mania and depression in a cohort of well characterized bipolar I and II patients who were followed prospectively for an average of three years.Method: Detailed life-charting data were obtained from 138 patients with bipolar disorder. Mood states were characterized as euthymic, subsyndromal, minor or major affective episodes based on rigorously defined criteria. The amount of time spent in these mood states during follow-up was examined.Results: Patients in the total sample and within each bipolar subtype spent approximately half of their time euthymic. The remainder of the time was spent in varying severity of mood states. However, the majority of time was spent with minor and subsyndromal symptoms, both manic and depressive. Bipolar I patients differ from bipolar II in that significantly more time was spent with subsyndromal, minor and manic symptoms. There was no difference in time spent with depressive symptoms between the two groups.Conclusions: Patients with bipolar disorder spend a substantial proportion of time with depressive or manic symptoms with the preponderance being minor or subsyndromal. Awareness of subthreshold symptoms in bipolar disorders and treatment of such symptoms may be improved by establishing guidelines that specifically outline appropriate strategies for reducing the duration of subsyndromal symptoms in bipolar disorder.