Stargazin differentially controls the trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors
Stargazin differentially controls the trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors
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DOI：
10.1124/mol.64.3.703
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发表时间：
2003-09-01
影响因子：
3.6
通讯作者：
Nicoll, RA
中科院分区：
文献类型：
--
作者：
Chen, L;El-Husseini, A;Nicoll, RA
大脑兴奋性突触的突触可塑性主要是通过突触α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯（AMPA）受体数量的快速变化实现的。Stargazin是一种与AMPA受体相互作用的膜蛋白，被认为在将AMPA受体运输到质膜并将其靶向突触中起关键作用。然而，目前尚不清楚红藻氨酸受体（结构上与AMPA受体非常相似）的运输是否也依赖于stargazin。在这里，我们表明，在小脑颗粒细胞和非洲爪蟾卵母细胞表达系统，红藻氨酸受体的表面传递是独立的stargazin。这些结果表明，stargazin的行动是高度选择性的AMPA受体。
Synaptic plasticity at excitatory synapses in the brain is largely achieved by rapid changes in the number of synaptic alpha-amino-3- hydroxyl-5-methyl-4-isoxazolepropionate ( AMPA) receptors. Stargazin, a membrane protein that interacts with AMPA receptors, is believed to play a pivotal role in trafficking AMPA receptors to the plasma membrane and targeting them to the synapse. However, it is unclear whether the trafficking of kainate receptors, which are structurally very similar to AMPA receptors, is also dependent on stargazin. Here we show that in both cerebellar granule cells and in Xenopus laevis oocytes expression system, surface delivery of kainate receptor is independent of stargazin. These results suggest that stargazin action is highly selective for AMPA receptors.