Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease
Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease
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DOI：
10.1038/s41598-020-71848-4
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发表时间：
2020-09-16
影响因子：
4.6
通讯作者：
Kudo, Masatoshi
中科院分区：
文献类型：
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作者：
Minaga, Kosuke;Watanabe, Tomohiro;Kudo, Masatoshi
IgG4相关疾病(IgG4-RD)是一种以血清IgG4浓度升高为特征的多器官自身免疫性疾病。虽然血清IgG4浓度被广泛用作IgG4-RD和1型自身免疫性胰腺炎(AIP)的生物标志物，1型自身免疫性胰腺炎(AIP)是IgG4-RD的胰腺表现，但相当数量的患者血清IgG4水平正常，即使在疾病活动期也是如此。最近，我们报道了实验性AIP和人类1型AIP的发展与胰腺中干扰素-α和IL-33的表达增加有关。在这项研究中，我们评估了血清干扰素-α和IL-33水平作为1型AIP和IgG4-RD的生物标志物的有效性。符合I型AIP和/或IgG4-RD诊断标准的患者血清干扰素-α和IL-33水平显著高于慢性胰腺炎患者和健康对照组。血清干扰素-α、IL-33和IgG4浓度之间有很强的相关性。根据受试者工作特征曲线分析，血清干扰素-α和IL-33浓度作为1型AIP和/或IgG4-RD标志物的诊断性能与血清IgG4浓度相当。强的松龙治疗诱导缓解后，这些细胞因子的血清浓度显著降低。我们认为，血清中的干扰素-α和IL-33浓度可作为I型AIP和IgG4-RD的生物标志物。
IgG4-related disease (IgG4-RD) is a multi-organ autoimmune disease characterized by elevated serum IgG4 concentration. Although serum IgG4 concentration is widely used as a biomarker for IgG4-RD and type 1 autoimmune pancreatitis (AIP), a pancreatic manifestation of IgG4-RD, a significant number of patients have normal serum IgG4 levels, even in the active phase of the disease. Recently, we reported that the development of experimental AIP and human type 1 AIP is associated with increased expression of IFN-alpha and IL-33 in the pancreas. In this study, we assessed the utility of serum IFN-alpha and IL-33 levels as biomarkers for type 1 AIP and IgG4-RD. Serum IFN-alpha and IL-33 concentrations in patients who met the diagnostic criteria for definite type 1 AIP and/or IgG4-RD were significantly higher than in those with chronic pancreatitis or in healthy controls. Strong correlations between serum IFN-alpha, IL-33, and IgG4 concentrations were observed. Diagnostic performance of serum IFN-alpha and IL-33 concentrations as markers of type 1 AIP and/or IgG4-RD was comparable to that of serum IgG4 concentration, as calculated by the receiver operating characteristic curve analysis. Induction of remission by prednisolone treatment markedly decreased the serum concentration of these cytokines. We conclude that serum IFN-alpha and IL-33 concentrations can be useful as biomarkers for type 1 AIP and IgG4-RD.