Solid phase synthesis of amides by the Beckmann rearrangement of ketoxime carbonates
Solid phase synthesis of amides by the Beckmann rearrangement of ketoxime carbonates
复制标题
DOI：
10.1016/j.tetlet.2003.09.113
复制
发表时间：
2003-11-17
影响因子：
1.8
通讯作者：
Greiner, A
中科院分区：
文献类型：
--
作者：
His, S;Meyer, C;Greiner, A
在三氟乙酸存在下，酮肟苄基碳酸酯发生贝克曼重排生成相应的酰胺。该反应通过将肟以衍生自羟甲基聚苯乙烯的混合碳酸酯的形式固定化而转化到固体载体上，以高效地产生多种酰胺。(C)2003 Elsevier Ltd.保留所有权利。
In the presence of trifluoroacetic acid, ketoxime benzyl carbonates undergo a Beckmann rearrangement to the corresponding amides. This reaction was translated to a solid support by immobilizing oximes in the form of mixed carbonates derived from hydroxymethyl polystyrene in order to produce a diversity of amides with high efficiency. (C) 2003 Elsevier Ltd. All rights reserved.