HIV-related lung cancer in the era of highly active antiretroviral therapy
HIV-related lung cancer in the era of highly active antiretroviral therapy
复制标题
DOI：
10.1097/00002030-200302140-00011
复制
发表时间：
2003-02-14
期刊：
影响因子：
3.8
通讯作者：
Gazzard, B
中科院分区：
文献类型：
--
作者：
Bower, M;Powles, T;Gazzard, B
目的：为了解决的影响，高效抗逆转录病毒治疗（HAART）的发病率和结果的患者与HIV相关的肺癌。设计和科目：HIV相关的肺癌患者被确定从1986年至2001年诊断的8400例患者的前瞻性艾滋病毒数据库。在1996年之前被诊断为HIV相关肺癌的患者在前HAART队列，而其余的是在后HAART cohol.Methods：HIV相关肺癌的发病率在前和后HAART队列进行了比较，与年龄和性别匹配的人口英格兰东南部。结果：HIV相关肺癌的发病率从HAART治疗前的0.8（95%CI 0.2-3.2）/10（5）患者年增加到HAART治疗后的6.7（95%CI 3.1-13.9）/105患者年。英格兰东南部年龄和性别匹配的肺癌发病率为0.75（95% CI 0.63-0.87）/10（5）患者-年，表明HIV相关肺癌仅在HAART后时期发生率更高（相对风险8.93，95% CI 4.92-19.98）。HAART前后的患者特征和结局相似，尽管HAART后患者检测HIV阳性和发生HIV相关肺癌之间的时间间隔更长。结论：在本研究中，与HIV阴性人群相比，HAART后时代HIV相关肺癌的发生率更高。不幸的是，这些患者的结果仍然很差，尽管HAART。(C)2003年利平科特威廉姆斯威尔金斯。
Objectives: To address the impact of highly active antiretroviral therapy (HAART) on the incidence and outcome of patients with HIV-related lung cancer.Design and subjects: Patients with HIV-related lung cancer were identified from a prospective HIV data base of 8400 patients diagnosed between 1986 and 2001. Patients diagnosed with HIV-related lung cancer before 1996 were in the pre-HAART cohort whereas the remainder were in the post-HAART cohort.Methods: The incidence of HIV-related lung cancer in the pre- and post-HAART cohorts was compared with the age and sex-matched population of south east England. Clinicopathological features, treatments and outcomes were also recorded.Results: The incidence of HIV-related lung cancer increased from 0.8 (95% Cl 0.2-3.2)/10(5) patient-years follow-up in the pre-HAART era to 6.7 (95% Cl 3.1-13.9)/105 patient-years follow-up in the post-HAART era. The age and sex-matched incidence of lung cancer in south east England was 0.75 (95% Cl 0.63-0.87)/10(5) patient-years, suggesting that HIV-related lung cancer only occurred more frequently in the post-HAART era (relative risk 8.93, 95% Cl 4.92-19.98). The patient characteristics and outcomes were similar in the pre- and post-HAART eras, although the time interval between testing HIV positive and developing HIV-related lung cancer was longer in post-HAART patients.Conclusion: In this study HIV-related lung cancer occurred more frequently in the post-HAART era, when compared with the HIV-negative population. Unfortunately, the outcome of these patients remains poor despite HAART. (C) 2003 Lippincott Williams Wilkins.