Systemic Lupus Erythematosus Prevalence in Sweden in 2010: What Do National Registers Say?
Systemic Lupus Erythematosus Prevalence in Sweden in 2010: What Do National Registers Say?
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DOI：
10.1002/acr.22355
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发表时间：
2014-11-01
影响因子：
4.7
通讯作者：
Svenungsson, Elisabet
中科院分区：
文献类型：
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作者：
Simard, Julia F.;Sjowall, Christopher;Svenungsson, Elisabet
目标。系统性红斑狼疮(SLE)的全球患病率估计在每10万人3至207人之间，这取决于地区和人口、SLE定义、病例来源和其他方法学考虑。我们的目标是在2010年1月1日利用基于人口的登记来确定瑞典系统性红斑狼疮的患病率。将多个国家登记联系起来，我们确定了2010年1月1日在瑞典登记的在世个人中，所有可能的住院和门诊就诊，以及SLE特定的出院诊断和相关的处方处方。SLE的定义从宽松的分类(只需要一次就诊)到更严格的定义，要求多次就诊并有相关专家护理的病史和普通SLE药物的配药。根据性别、年龄(0-14岁、15-49岁、=50岁，以及5岁年龄组)和居住县计算患病率。总体患病率从最严格定义的每10万人46人到最不严格的定义每10万人85人不等。正如预期的那样，系统性红斑狼疮在女性(79-144/100,000)中比男性(12-25/100,000)更常见，并因年龄而异。各县的差异高达4倍，这是意想不到的。患病率一般随年龄增长而增加(根据年龄增长，0-14岁、15-49岁和<50岁分别为2/10万、52/10万和95/10万)，并因县而异。患病率按年龄和性别的变化与之前的研究一致，总体范围为每10万人中有46至85人。根据多种定义，我们在2010年1月1日观察到瑞典系统性红斑狼疮的患病率出现了令人惊讶的地域差异。
Objective. Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3 to 207 per 100,000, depending on region and population, SLE definition, case sources, and other methodologic considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010, using population-based registers.Methods. Linking multiple national registers, we identified all possible inpatient and outpatient visits with SLE-specific discharge diagnoses and relevant prescription dispensations among living individuals registered in Sweden on January 1, 2010. SLE was defined from a lenient classification (requiring only a single visit) to stricter definitions that required multiple visits with a history of relevant specialist care and a dispensation for common SLE medications. Prevalence was calculated overall and by sex, age (0-14 years, 15-49 years, and >= 50 years, as well as in 5-year age groups), and county of residence.Results. Overall prevalence ranged from 46 per 100,000 for the strictest definition to 85 per 100,000 for the least strict definition. As expected, SLE was more common among females (range 79-144 per 100,000) than males (range 12-25 per 100,000) and varied by age. The up to 4-fold variation by county was unexpected. Prevalence generally increased with age (2, 52, and 95 per 100,000 by increasing age group, 0-14 years, 15-49 years, and >= 50 years, respectively, using a moderately strict definition) and also varied by county.Conclusion. Variations of prevalence by age and sex were consistent with previous studies and overall ranged from 46 to 85 per 100,000. We observed a surprising geographic variation in the prevalence of SLE in Sweden on January 1, 2010, according to multiple definitions.