Improving the accuracy of retrieved cardiac electrical conductivities.
Improving the accuracy of retrieved cardiac electrical conductivities.
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DOI：
10.21914/anziamj.v63.17148
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发表时间：
2022
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bidomain模型的六个心脏电导率的准确值对于心脏组织的有意义的电生理模拟是至关重要的，并且尚未实现。一个两阶段的优化过程是用来检索心脏电导率从心脏电位上测量的多电极阵列的第一阶段同时适合所有六个电导率，和第二阶段适合的电导率（细胞内电导率）的子集，而保持其余的电导率（细胞外电导率）恒定。以前的研究表明，细胞内电导率检索到的准确度低于细胞外电导率。本研究测试的命题，存在的细胞外和细胞内的电导率之间的关系，在第二阶段的优化，影响检索的细胞内电导率的准确性。利用多项式混沌的措施来量化这种关系。结果表明，一个显着的关系确实存在，因此，在细胞外电导率的任何错误被放大的检索细胞内电导率。因此，它建议，未来的协议检索电导率将在细胞外电导率的不确定性。
Accurate values for the six cardiac conductivities of the bidomain model are crucial for meaningful electrophysiological simulations of cardiac tissue and are yet to be achieved. A two-stage optimisation process is used to retrieve the cardiac conductivities from cardiac potentials measured on a multi-electrode array—the first stage simultaneously fits all six conductivities, and the second stage fits a subset of the conductivities (intracellular conductivities), while holding the remainder of the conductivities (extracellular conductivities) constant. Previous studies have shown that the intracellular conductivities are retrieved to a lesser degree of accuracy than extracellular conductivities. This study tests the proposition that there exists a relationship between the extracellular and intracellular conductivities during the second stage of the optimisation that affects the accuracy of the retrieved intracellular conductivities. A measure to quantify this relationship is developed using polynomial chaos. The results show that a significant relationship does exist, and thus any errors in the extracellular conductivities are magnified in the retrieved intracellular conductivities. Thus, it is suggested that future protocols for retrieving conductivities incorporate the uncertainty in the extracellular conductivities.