CHARACTERIZATION OF THE MIDDLE CAPILLARY PLEXUS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN HEALTHY AND DIABETIC EYES.
CHARACTERIZATION OF THE MIDDLE CAPILLARY PLEXUS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN HEALTHY AND DIABETIC EYES.
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DOI：
10.1097/iae.0000000000001077
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Fawzi AA
中科院分区：
文献类型：
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作者：
Park JJ;Soetikno BT;Fawzi AA
评估光学相干断层扫描血管造影术（OCTA）对视网膜中毛细血管丛（MCP）成像的能力，并将MCP表征为独立于浅表（SCP）和深毛细血管丛（DCP）的独特血管网络。使用Avanti XR OCTA仪器（Optovue Inc，Fremont，加州，美国）对健康和糖尿病眼睛成像。使用视网膜层的手动分割，我们生成了面部血管造影片来区分三个毛细血管丛（SCP，MCP，DCP）。在健康眼，微动脉在MCP中产生明显的分支，而微静脉在DCP中产生突出的漩涡状分支。中央凹无血管区（FAZ）在MCP水平最清晰，在DCP中面积较大。在糖尿病眼中，三个毛细血管丛表现出不同程度的非灌注，包括可变形状和范围的FAZ，在MCP的边界完整性的损失。3个毛细血管丛均出现微动脉瘤。在OCTA中使用定制的分割分析，我们证明MCP在定性和功能上不同于SCP和DCP，这可能有助于阐明不同的中间视网膜缺血实体的发病机制，并为糖尿病视网膜病变中的视网膜缺血提供新的见解。
To assess the ability of optical coherence tomography angiography (OCTA) to image the retinal middle capillary plexus (MCP), and to characterize the MCP as a unique vascular network separate from the superficial (SCP) and deep capillary plexus (DCP). Healthy and diabetic eyes were imaged using the Avanti XR OCTA instrument (Optovue Inc, Fremont, California, USA). Using manual segmentation of the retinal layers, we generated en face angiograms to distinguish the three capillary plexuses (SCP, MCP, DCP). In healthy eyes, arterioles gave rise to distinct branches in the MCP, and venules gave rise to prominent vortex like branches in the DCP. The foveal avascular zone (FAZ) was most well-defined at the level of the MCP, and had a larger area in the DCP. In diabetic eyes, the three capillary plexuses showed varying degrees of non-perfusion, including variable shapes and extent of the FAZ, with loss of border integrity at the MCP. Microaneurysms appeared in all of the three capillary plexuses. Using customized segmentation analysis in OCTA, we demonstrate that the MCP is qualitatively and functionally distinct from the SCP and DCP, which may help clarify the pathogenesis of different middle retinal ischemic entities and provide new insights into retinal ischemia in diabetic retinopathy.