ALLYLAMINE CARDIOTOXICITY .4. METABOLISM TO ACROLEIN BY CARDIOVASCULAR TISSUES
ALLYLAMINE CARDIOTOXICITY .4. METABOLISM TO ACROLEIN BY CARDIOVASCULAR TISSUES
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DOI：
10.1016/0006-2952(82)90152-6
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发表时间：
1982-01-01
影响因子：
5.8
通讯作者：
BOOR, PJ
中科院分区：
文献类型：
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作者：
NELSON, TJ;BOOR, PJ
丙烯醛在与烯丙胺孵育的大鼠主动脉、肺、骨骼肌和心脏匀浆中检测到。在大鼠体内，对烯丙胺诱导的心肌损伤具有保护作用的森巴肼和肼苯哒嗪抑制丙烯醛的形成。在烯丙胺氧化过程中产生氧化脱氨产物H2O2。丙烯醛也产生烯丙胺由牛血浆胺氧化酶和猪肾二胺氧化酶，但不是由大鼠肝或脑匀浆。烯丙胺竞争性抑制大鼠主动脉中的苄胺氧化，但帕吉林敏感的单胺氧化酶不参与丙烯醛的产生。主动脉中的高活性、与苄胺的竞争性以及对苄胺氧化酶抑制剂的敏感性，表明苄胺氧化酶是氧化烯丙胺的活性酶。丙烯醛的形成可能是烯丙胺心脏毒性作用的基础。
Acrolein was detected in homogenates of rat aorta, lung, skeletal muscle and heart incubated with allylamine. Semicarbazide and hydralazine, which protect against allylamine-induced myocardial injury in vivo in the rat, inhibited acrolein formation. H2O2, a product of oxidative deamination, was generated during allylamine oxidation. Acrolein was also produced from allylamine by bovine plasma amine oxidase and porcine kidney diamine oxidase but not by rat liver or brain homogenates. Allylamine competitively inhibited benzylamine oxidation in rat aorta, but pargyline-sensitive monoamine oxidase was not involved in acrolein production. The high activity in aorta, the competition with benzylamine and the sensitivity to benzylamine oxidase inhibitors evidently indicates that benzylamine oxidase was the active enzyme in oxidizing allylamine. The formation of acrolein may be the basis of the cardiotoxic action of allylamine.