Antioxidative and acute antiinflammatory effects of Torreya grandis
Antioxidative and acute antiinflammatory effects of Torreya grandis
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DOI：
10.1016/j.fitote.2006.03.019
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发表时间：
2006-06-01
期刊：
影响因子：
3.4
通讯作者：
Yun, Yeo-Pyo
中科院分区：
文献类型：
--
作者：
Chen, Bao-Qiong;Cui, Xiang-Yu;Yun, Yeo-Pyo
研究香榧种子乙醇提取物（EST）的抗氧化和抗氧化活性。将人皮肤成纤维细胞暴露于50和250 μ g/ml的浸提液中，显示出对过氧化氢（300 μ M）的显著保护作用。EST不仅能保护H2 O2诱导的细胞存活，而且能显著抑制H2 O2诱导的LDH释放。在黄嘌呤/黄嘌呤氧化酶体系中，100和1000 μ g/ml的EST对DPPH自由基和超氧阴离子自由基的抑制率分别为29.8%和100.0%，对超氧阴离子自由基的抑制率分别为41.2%和98.4%。局部应用EST剂量依赖性地抑制花生四烯酸（AA）和12-O-十四酰基佛波醇-13-乙酸酯（TPA）诱导的小鼠耳水肿。(c)2006年由Elsevier B. V.出版
The present study was undertaken to investigate the antioxidative and antiinflammatory activities of the ethanolic extract of seeds of Torreya grandis (EST). Exposure of human dermal fibroblasts to the extract at 50 and 250 mu g/ml showed significant protective effect against hydrogen peroxide (300 mu M). EST not only protected cell survival from H2O2-induced toxicity, but also inhibited the H2O2-induced LDH release significantly. It was also found that EST at 100 and 1000 mu g/ml showed scavenging activities of radicals and reactive oxygen species with 29.8% and 100.0% of inhibition against DPPH radical and 41.2% and 98.4% against superoxide radicals in the xanthine/xanthine oxidase system, respectively. Topically applied EST dose-dependently inhibited arachidonic acid (AA)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. (c) 2006 Published by Elsevier B.V.