NATURAL-HISTORY OF MINUTE HEPATOCELLULAR-CARCINOMA SMALLER THAN .3. CENTIMETERS COMPLICATING CIRRHOSIS - A STUDY IN 22 PATIENTS
NATURAL-HISTORY OF MINUTE HEPATOCELLULAR-CARCINOMA SMALLER THAN .3. CENTIMETERS COMPLICATING CIRRHOSIS - A STUDY IN 22 PATIENTS
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DOI：
10.1016/0016-5085(86)90923-6
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发表时间：
1986-02-01
期刊：
影响因子：
29.4
通讯作者：
OKUDA, K
中科院分区：
文献类型：
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作者：
EBARA, M;OHTO, M;OKUDA, K
对22例肝硬化和直径<3cm的微小肝癌患者进行了6-37个月的随访，未进行特殊治疗。Kaplan-Meier法绘制的生存曲线显示1年生存率为90.7%，2年生存率为55.0%，3年生存率为12.8%。这些肿块在肝脏中的超声模式与大小相关，并表现出从低回声模式到低周边，最后到巨大模式的趋势。从肿瘤体积的倍增时间计算的生长速度在不同情况下变化很大，平均为6.5 ± 1.5。5.7在观察期间，在某些情况下也发生了变化。血清α甲胎蛋白水平通常较低，很少辅助诊断，但当肿块达到> 3cm的直径时倾向于增加; α-甲胎蛋白水平增加速率突然加速。甲胎蛋白水平常与超声声像图向块状改变相一致。
Twenty-two patients with cirrhosis and minute hepatocellular carcinoma < 3 cm in diameter were followed for periods of 6-37 mo without specific treatment. The survival curve drawn by the Kaplan-Meier method showed a 1-yr survival of 90.7%, a 2-yr survival of 55.0%, and a 3-yr survival of 12.8%. The ultrasonic patterns of these masses in the liver were correlated with the size and showed a tendency to change from a low echo pattern to a low periphery and, finally, to a massive pattern. The growth speed calculated from the doubling time for tumor volume varied considerably from case to case with an average of 6.5 .+-. 5.7 mo; it also changed in some cases during the observation period. Serum .alpha.-fetoprotein levels were generally low, rarely assisted in diagnosis, but tended to increase when the mass attained a diameter of > 3 cm; sudden aceleration in the rate of increase in .alpha.-fetoprotein level often coincided with a change of ultrasonic pattern to the massive one.