Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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DOI：
10.1044/2020_ajslp-20-00007
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发表时间：
2020-11-01
影响因子：
2.6
通讯作者：
Henry, Maya L.
中科院分区：
文献类型：
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作者：
Europa, Eduardo;Iaccarino, Leonardo;Henry, Maya L.
目的：原发性进行性失语症（PPA）的诊断和分类需要确认特定的言语和语言症状，这凸显了言语 - 语言病理学家在评估过程中的重要作用。本病例报告的目的是向言语 - 语言病理学家介绍PPA诊断评估的现行做法，描述标准方法以及可能提高诊断准确性的补充性的先进程序。
方法：我们描述了对一名49岁女性的诊断评估，该女性主诉进行性找词困难。她完成了标准的神经学、神经心理学和言语 - 语言评估，以及脑部的磁共振成像和正电子发射断层扫描成像。此外，还获取了其发育过程中的言语、语言和学习能力史，以及基因检测和脑脊液生物标志物评估。我们结合与PPA诊断相关的最新研究讨论了评估结果。
结论：详细的行为评估、全面了解症状史和神经发育差异、多模式神经影像学以及对基因和生物标志物的综合检查对于检测和描述PPA至关重要，这对早期行为和/或药物干预具有重要意义。
Purpose: Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the- art procedures that may improve diagnostic precision.Method: We describe the diagnostic evaluation of a 49-yearold woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis.Conclusion: Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention.