Development of the Mouse Placenta.
Development of the Mouse Placenta.
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DOI：
10.1007/978-3-030-77360-1_10
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发表时间：
2021
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影响因子：
--
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中科院分区：
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胎盘在子宫内形成为一个短暂的器官，只有当妇女怀孕时才有一系列活动。它是由母体和胚胎成分组成的盘状杂交结构。它在胚泡植入后在子宫的系膜侧发育，以保持两个遗传上不同的实体，母亲和胚胎，分离但连接。胚泡植入后胎盘形成和发育的开始和进展与胚胎的时间发育阶段相一致。它逐渐获得同步执行血管、呼吸、肝脏、肾脏、内分泌、胃肠道、免疫和物理屏障功能的能力，这些功能对胎儿发育、生长和母体环境内的安全至关重要。当胚胎生长和生存支持作用完成时，子宫将胎盘排出;这通常是婴儿的出生。尽管它在胚胎发育和妊娠后的生存中具有不可替代的作用，但它如何形成，成熟，执行其所有活动并开始失效仍不清楚。因此，详细了解胎盘的正常发育，结构和功能方面可能会导致避免胎盘出现的妊娠问题。
Placenta forms as a momentary organ inside the uterus with a slew of activities only when the woman is pregnant. It is a discoid-shaped hybrid structure consisting of maternal and embryonic components. It develops in the mesometrial side of the uterus following blastocyst implantation to keep the two genetically different entities, the mother and embryo, separated but connected. The beginning and progression of placental formation and development following blastocyst implantation coincides with the chronological developmental stages of the embryo. It gradually acquires the ability to perform the vascular, respiratory, hepatic, renal, endocrine, gastrointestinal, immune, and physical barrier functions synchronously that are vital for fetal development, growth, and safety inside the maternal environment. The uterus ejects the placenta when its embryonic growth and survival supportive roles are finished; that is usually the birth of the baby. Despite its irreplaceable role in fetal development and survival over the post-implantation progression of pregnancy, it still remains unclear how it forms, matures, performs all of its activities, and starts to fail functioning. Thus, a detailed understanding about normal developmental, structural, and functional aspects of the placenta may lead to avoid pregnancy problems that arise with the placenta.
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